This study is about understanding how a condition called pachychoroid changes over time. Pachychoroid refers to an anatomic choroidal characteristic with abnormally thick choroid or abnormally dilated Haller's vessels. Pachychoroid can range from mild forms which does not cause any problems to more serious ones that might cause vision loss.This study will recruit participants with pachychoroid, to learn more about how this condition develops, how it affects people in the long run, and what factors might make it worse.
Eligibility
Sex
ALL
Min age
45 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
1. Adults aged 45 years or older.
2. Presence of pachyvessels on ultra-widefield (UWF) imaging in at least one quadrant.
3. Willing to undergo pupil dilation, and protocol-required procedures for both eyes
4. Willing to provide written informed consent
Exclusion Criteria:
1. Presence of disorders of the ocular media which interfere with visual acuity and other ocular assessments during the study period
2. Eyes with other ocular pathology such as trauma, inflammation, previous intraocular surgery (except for cataract surgery)
3. Systemic diseases that might affect ocular blood flow such as uncontrolled hypertension, autoimmune disease, and haematological disorders
4. Pregnant or nursing women
5. Persons who are unable to give informed consent
Primary outcome measure(s)
Progression of choroidal venous alterations — 3 years Proportion of eyes demonstrating progression of choroidal venous alterations, defined as either an increase in number of quadrants with pachyvessels or formation of new choroidal anastomoses.
Trial sites (4)
Facility
City
Region
Status
Hong Kong University
Hong Kong
Hong Kong
Recruiting
University of Malaya Medical Centre
Kuala Lumpur
Malaysia
Recruiting
National University Hospital, Singapore
Singapore
Singapore
Recruiting
Singapore National Eye Centre/ Singapore Eye Research Institute
Singapore
Singapore
Recruiting
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This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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