FITME Study: Formulating Individualised Exercise Prescription in Chronic Obstructive Pulmonary Disease

Condition(s) studied

Investigational drug(s) / intervention(s)

Pulmonary rehabilitation programme: Participants will undergo a supervised, in-person pulmonary rehabilitation programme lasting for twelve weeks, twice a week. The intervention comprises cardiorespiratory exercise training, conducted on either a treadmill or a cycle ergometer. Exercise intensity will be individually prescribed based on the power output registered at the first metabolic threshold, during a baseline cardiopulmonary exercise test. For treadmill exercise prescription, guideline-based estimation equations will be used to estimate treadmill velocity based on the oxygen uptake obtained in the first metabolic threshold. Resistance training will be provided in the same sessions as internationally recommended. Progress will occur on weekly basis, according to symptoms. Education and psychosocial support will also be provided once every other week. All sessions will range from 60-90 minutes.

Pulmonary rehabilitation programme: Standard of care (pulmonary rehabilitation programme featuring six-minute walking test-derived cardiorespiratory exercise prescription).

Study summary

This randomised controlled trial aims to: i) compare the power output at the first metabolic threshold (WMT1) between the MT1 and the six-minute walking test (6MWT)-based cardiorespiratory exercise prescriptions in chronic obstructive pulmonary disease (COPD); ii) compare exercise adherence, peripheral muscle strength, health-related quality of life, dyspnoea, fatigue, disease impact and emotional status between MT1 and 6MWT-based exercise prescriptions.

Patients will be recruited via the pulmonology services from Unidade Local de Saúde do Baixo Mondego and Unidade Local de Saúde de Aveiro.

Eligibility

Primary outcome measure(s)

• Exercise capacity - Power output at first metabolic threshold — From baseline (pre-intervention) to the end of the pulmonary rehabilitation programme (12 weeks)
  Power output at first metabolic threshold will be measured during a cardiopulmonary exercise test (watts).

Trial sites (1)

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