AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause. The study will include healthy women aged 40 to 64 years living in Portugal, who will provide stool and blood samples and complete questionnaires about their health, lifestyle, diet, and menopausal symptoms. Researchers will study the gut microbiome together with hormone levels and markers of inflammation to better understand how menopause affects long-term health and to support the development of improved prevention strategies for women.
Eligibility
Sex
FEMALE
Min age
40 Years
Max age
64 Years
Healthy volunteers
No
Inclusion Criteria:
* Female sex
* Aged 40 to 64 years
* Resident in mainland Portugal or the islands
* Able and willing to provide written informed consent
* Willing to provide stool and blood samples and complete three questionnaires
Exclusion Criteria:
* Age below 40 years or 65 years and older
* Inability to give informed consent
* Refusal to provide stool or blood samples or complete questionnaires
* Pregnancy
* Diagnosed gastrointestinal disorders (including inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic diarrhoea of unknown cause, or recurrent Clostridioides difficile infection)
* Active oncological disease
Primary outcome measure(s)
Gut microbiome functional profile. — Baseline and every 2 years over a period of 10 years. Changes in microbial gene functions and metabolic pathways derived from metagenomic analysis.
Gut microbiome taxonomic composition — Baseline and 2 years over a period of 10 years. Changes in faecal microbiome composition assessed by shotgun metagenomic sequencing across menopause stages.
Trial sites (1)
Facility
City
Region
Status
Gulbenkian Institute for Molecular Medicine, Lisbon
Lisbon
Portugal
Recruiting
More Gulbenkian Institute for Molecular Medicine trials in Portugal
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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