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XR2ESILIENCE - XR-Based Resilience Training for Stress and Mental Health in Healthcare Workers

NCT07544498 · tracked via the Priya Life Science Portugal tracker
Phase
Not applicable
Started
2026-09
Last updated
2026-05-18

Condition(s) studied

Occupational StressWork-Related StressMental HealthBurnoutResilience

Investigational drug(s) / intervention(s)

XR-based Resilience TrainingWaitlist Control

XR-based Resilience Training: The XR-based resilience training is delivered via a standalone extended reality head-mounted display and consists of eight immersive sessions over approximately ten weeks. The training addresses behavioral coping strategies such as problem solving, cognitive coping strategies such as appraisal and reappraisal of stressors, and emotional coping strategies including emotion regulation and positive self-care. Sessions last approximately 20 to 30 minutes and are completed individually with technical support available if needed.

Waitlist Control: Participants assigned to the waitlist control condition receive no active intervention during the initial study period and continue with care as usual. After completion of the post-intervention assessment, participants are offered access to the XR-based resilience training.

Study summary

This study investigates the effectiveness of an extended reality (XR) based resilience training program designed to support the mental health and well-being of nurses working in hospital settings. Nurses are exposed to high emotional, cognitive, and organizational demands and show elevated levels of work-related stress and stress-associated mental health problems. Strengthening resilience and coping capacities is therefore an important preventive approach to support nurses' well-being and sustain quality of care.

The study is conducted as a pragmatic randomized controlled trial with a waitlist control group and includes approximately 232 nurses from hospitals in several European countries. Participants are randomly assigned either to an XR-based resilience training group or to a waitlist control group that continues with care as usual during the waiting period. The XR-based intervention consists of eight immersive training sessions delivered over approximately ten weeks using a head-mounted display. The training focuses on behavioral, cognitive, and emotional coping strategies and aims to enhance key resilience factors such as problem-solving, cognitive reappraisal, emotion regulation, and positive self-care.

The primary outcome is perceived stress, assessed using the Perceived Stress Scale. Secondary outcomes include resilience, occupational self-efficacy, quality of life, psychological distress, burnout symptoms, coping strategies, work-related rumination, and turnover intentions. Assessments are conducted at baseline, post-intervention, and at a 20-week follow-up. In addition, a subgroup of participants will optionally provide physiological data during selected XR sessions to explore digital biomarkers related to stress and recovery.

The findings of this study will provide evidence on the effectiveness, feasibility, and acceptance of XR-based resilience training for nurses and inform future implementation of digital mental health interventions in healthcare workplaces.

Eligibility

Sex
ALL
Min age
18 Years
Max age
65 Years
Healthy volunteers
Accepted
Inclusion Criteria: 1. working as a nurse in direct patient care within a clinical setting; 2. working at least 10h/week in their profession; 3. speaking the language in which the RCT is conducted sufficiently well; 4. able and willing to participate in all aspects of the study; 5. understanding and signing the appropriate informed consent form. Exclusion Criteria: 1. a diagnosed severe mental disorder associated with alterations in reality perception (e.g., delusions, hallucinations, derealization, depersonalization, or dementia), including in particular schizophrenia, bipolar disorder, severe major depressive disorder, or other psychotic disorders (lifetime); 2. a current major depressive episode or a current post-traumatic stress disorder (PTSD); 3. an acute or clinically significant medical condition that may interfere with the safe use of an XR headset or study participation, including but not limited to epilepsy, pronounced dizziness, balance disorders, or acute cardiovascular conditions; 4. an acute eye infection (e.g., conjunctivitis); 5. unstable medication related to a mental health condition, defined as recent changes in dosage or class of psychotropic medication; 6. initiation of psychotherapy or any structured stress-management training within the past three months.

Primary outcome measure(s)

Trial sites (8)

FacilityCityRegionStatus
Medical University of Graz, Clinical Division of Psychiatry and Psychotherapeutic Medicine Graz Styria
Klinika za psihijatriju Sveti Ivan Zagreb Croatia
University Medical Center of Johannes Gutenberg University Mainz Mainz Rhineland-Palatinate
Hospital José Joaquim Fernandes Beja Beja District
Del Henares University Hospital Coslada Madrid
Summa 112 Madrid Madrid
Infanta Leonor University Hospital Madrid Madrid
Infanta Sofía University Hospital San Sebastián de los Reyes Madrid

Other trials for the same condition

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07544498 on ClinicalTrials.gov ↗ ← All trials in Portugal