Amyotrophic Lateral Sclerosis: A Multicenter Retrospective Observational Registry

Condition(s) studied

Investigational drug(s) / intervention(s)

Imaging and Clinical Reports: Inclusion of existing imaging data (MRI, EMG reports) and standard clinical documentation, where available.

Study summary

This retrospective observational study will analyze de-identified clinical data from patients with amyotrophic lateral sclerosis (ALS) collected at multiple centers over 7 years. The primary objective is to describe disease progression using the ALS Functional Rating Scale-Revised (ALSFRS-R). Secondary objectives include evaluating survival, ventilatory decline, and correlations between available biomarkers (e.g., neurofilament light chain, cytokines) and disease trajectory. No new interventions or patient contact will occur.

Eligibility

Primary outcome measure(s)

• Rate of decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores — 2 yearss after the first administration
  Unit: points per month

Trial sites (1)

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