Patient-Ventilator Asynchrony: Occurence and Clinical Impact in Usual Care

NCT07624786 · tracked via the Priya Life Science Netherlands tracker

Sponsor

Erasmus Medical Center

Phase

Observational

Started

2026-07-21

Last updated

2026-08-13

Condition(s) studied

Mechanical VentilationPatient-Ventilator Asynchrony

Investigational drug(s) / intervention(s)

PVA classification software

PVA classification software: Patients will receive standard care, without an intervention. Data will be captured as part of standard care and analyzed for PVAs retrospectively, using dedicated offline software.

Study summary

The goal of this observational study is to unravel the occurence, impact and relations of Patient-Ventilator Aynchrony (PVA) in mechanically ventilated patients. The main questions it aims to answer are:

* How often does PVA occur?
* What are relations between clinical characteristics and PVA occurence?
* What are relations between PVA occurence and patient outcomes?

All questions will be assessed using data collected during the whole course of mechanical ventilation. Mechanically ventilated patients' medical data will be re-used. PVAs will be automatically classified on ventilator waveform data, using validated Deep Breath software.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age \> 18 years old. * Recordings available of ventilator waveforms synchronized with the patient's electronic health record during invasive mechanical ventilation. * Duration of mechanical ventilation of at least 24 hours. Exclusion Criteria: * (Previous) registered objection of patient and/or relatives to re-use clinical data for research purposes * No consent for re-use of data for research

Primary outcome measure(s)

Asynchrony index over time (aggregated and per PVA type) — 28 days
Measure of how much asynchrony occurs and at what time. This measure will be calculated for all PVA types together, as well as per PVA type. The investigators calculate this over time, to see when asynchrony occurs, as well as in total, to get a global PVA prevalence measure (over the whole duration of ventilation).

Trial sites (3)

Facility	City	Region	Status
Catharina Ziekenhuis Eindhoven (CZE)	Eindhoven	North Brabant	Recruiting
Leiden University Medical Center (LUMC)	Leiden	South Holland	Not Yet Recruiting
Erasmus Medical Center (EMC)	Rotterdam	South Holland	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07624786 on ClinicalTrials.gov ↗ ← All trials in the Netherlands