Critical IllnessIntensive Care Units (ICUs)Weaning FailureMechanical VentilationSpontaneous Breathing TrialDiaphragm Electrical ActivityOxygen Consumption
Study summary
The goal of this observational study is to measure effort using esophageal pressure measurements, oxygen consumption and diaphragm activity in mechanically ventilated Intensive Care Unit patients during a Spontaneous Breathing Trial. The main question aims to answer whether the sEMG signal derived from the SERA device, effort parameters and oxygen consumption have an association with weaning failure.
Participants will be measured while performing a spontaneous breathing trial.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* 18 years of age or older
* Esophageal catheter in situ (standard of care)
* Eligible for an SBT in the near future according to the LUMC SBT protocol currently valid
Exclusion Criteria:
* Severe cardiac failure NYHA class IV without mechanical support (LVAD or Impella)
* COPD Gold IV
* Pregnancy
* Patients with ECMO
Primary outcome measure(s)
Extubation failure — 48 hours after extubation Extubation failure is defined by the need for reintubation or death.
sEMG differences during SBT — 10 minutes before switch from support to no support ventilation, the whole duration of the SBT, and the 10 minutes after the SBT when there is again support. The AUC of the voltage signal, the phasic level (difference between tonic level and maximum level) and the tonic level (base level).
Trial sites (1)
Facility
City
Region
Status
Leiden University Medical Centre
Leiden
Netherlands
Recruiting
More Leiden University Medical Center trials in the Netherlands
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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