Outbreaks with viruses occur continuously, and novel viruses or new variants of existing viruses can surface after a zoonotic event or human-to-human transmission. This project proposal is designed to detect early circulation of (novel) respiratory viruses in both symptomatic and asymptomatic participants, either by direct detection of the virus or changes in local or systemic immunity. Additionally, SENTINEL will provide information on infectivity and (protective) immune responses in viral outbreaks or vaccination campaigns.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
* 18 years or older
* Health care workers with or without direct patient contact
* Animal workers with or without direct animal contact
Exclusion Criteria:
* \<18 years
Primary outcome measure(s)
Main study endpoint — 60 months Identification of circulating respiratory viruses by targeted molecular testing in symptomatic participants
Main study endpoint — 60 months Identification of circulating respiratory viruses by metagenomic sequencing in symptomatic participants
Main study endpoint — 60 months Identification of circulating respiratory viruses by virus culture in symptomatic participants
Main study endpoint — 60 months Longitudinal monitoring of local immune responses, for example by, but not limited to, quantitative, qualitative and/or functional antibody assays (ELISA, VNT, PRNT) to detect changes as a proxy for asymptomatic exposure to respiratory viruses.
Main study endpoint — 60 months Longitudinal monitoring of systemic immune responses, for example by, but not limited to, quantitative, qualitative and/or functional antibody assays (ELISA, VNT, PRNT) to detect changes as a proxy for asymptomatic exposure to respiratory viruses.
Trial sites (1)
Facility
City
Region
Status
ErasmusMC
Rotterdam
South Holland
Recruiting
More Erasmus Medical Center trials in the Netherlands
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
We use cookies to analyse site traffic and improve your experience. With your consent, we may also use cookies for advertising. You can change your choice at any time.
