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Clinical Trials in the Netherlands / NCT06824961
Recruiting Not applicable

Does Increasing the Compression Pause From 3 to 5 Seconds in Mechanical Compression Devices Increase Ventilation Success Rate and Return of Spontaneous Circulation?

NCT06824961 · tracked via the Priya Life Science Netherlands tracker
Sponsor
Amsterdam UMC, location VUmc
Phase
Not applicable
Started
2026-01-15
Last updated
2026-08-21

Condition(s) studied

Cardiac Arrest (CA)

Investigational drug(s) / intervention(s)

5-second ventilation pause duration during mechanical CPR3-second ventilation pause duration during mechanical CPR

5-second ventilation pause duration during mechanical CPR: The intervention is a 5-second lasting ventilation pause during mechanical CPR

3-second ventilation pause duration during mechanical CPR: The intervention is a 3-second lasting ventilation pause during mechanical CPR

Study summary

To give chest compressions during cardiopulmonary resuscitation (CPR), mechanical chest compression devices can be used. During synchronous 30:2 CPR, the standard setting on these devices leave an automated 3-second chest compression pause after 30 compressions to facilitate caregivers in providing two ventilations. With this standard setting, research has shown that in less than half of ventilation pauses during CPR, those two ventilations are given. Increasing the ventilation pause duration to 5 seconds instead of 3 seconds is also an option following current guideline recommendations, and aligns with measured ventilation pause duration in manual CPR. Increasing pause duration to 5 seconds could result in an increased ventilation success rate. This multicenter randomized controlled trial will randomize LUCAS® mechanical compression devices to a standard setting of 3- or 5-second compression pauses. The main outcome will be the percentage of ventilation pauses in which two ventilations are successfully given. Secondary outcomes include the restoration of spontaneous circulation (ROSC), and the difference in (neurologically intact) survival. No study has been performed to evaluate this effect yet.

Eligibility

Sex
ALL
Min age
16 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adults (≥16 years of age) * OHCA patients with an attempt at cardiopulmonary resuscitation (CPR) by ambulance personnel * LUCAS® 3.1 has been used during the resuscitation attempt Exclusion Criteria: * Missing ambulance run report, missing or unclear impedance signal (measurement of resistance across the thorax), making it impossible to assess the number of ventilation pauses * Absence of a minimum of 3 assessable pauses intended for ventilation after connecting the LUCAS®

Primary outcome measure(s)

Trial sites (2)

FacilityCityRegionStatus
Ambulance Amsterdam Amsterdam North Holland Recruiting
Regionale Ambulance Voorziening Kennemerland - Ambulancezorg GGD Kennemerland Haarlem North Holland Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06824961 on ClinicalTrials.gov ↗ ← All trials in the Netherlands