A Study of Lebrikizumab (LY3650150) in Participants 6 Months to <18 Years of Age With Moderate-to-Severe Atopic Dermatitis
Condition(s) studied
Investigational drug(s) / intervention(s)
Lebrikizumab: Administered SC
Placebo: Placebo given SC
Topical Corticosteroid (TCS): TCS administered
Study summary
The main purpose of this study is to measure the effect, safety and how well the body absorbs lebrikizumab in pediatric participants 6 months to \<18 years of age with moderate-to-severe atopic dermatitis (AD).
Eligibility
Primary outcome measure(s)
- Percentage of Participants with an Investigator Global Assessment (IGA) score 0 or 1 and a Reduction ≥2 points from Baseline — Baseline to Week 16
EASI-75 is a co-primary endpoint with IGA. - Percentage of Participants Achieving Eczema Area and Severity Index-75 (EASI-75) ≥75% Reduction from Baseline in EASI Score — Baseline to Week 16
IGA is a co-primary endpoint with EASI-75.
Trial sites (85)
| Facility | City | Region | Status |
|---|---|---|---|
| Clinical Research Center of Alabama | Birmingham | Alabama | |
| Phoenix Children's Hospital | Phoenix | Arizona | |
| Arkansas Research Trials | North Little Rock | Arkansas | |
| First OC Dermatology | Fountain Valley | California | |
| Antelope Valley Clinical Trials | Lancaster | California | |
| Dermatology Research Associates | Los Angeles | California | |
| Integrative Skin Science and Research | Sacramento | California | |
| Rady's Children Hospital San Diego - Dermatology | San Diego | California | |
| UConn Health | Farmington | Connecticut | |
| Solutions Through Advanced Research | Jacksonville | Florida | |
| ForCare Clinical Research | Tampa | Florida | |
| Treasure Valley Medical Research | Boise | Idaho | |
| Northwestern University | Chicago | Illinois | |
| Allergy & Asthma Specialists, P.S.C. | Owensboro | Kentucky | |
| Respiratory Medicine Research Institute of Michigan, PLC | Ypsilanti | Michigan | |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | |
| Psoriasis Treatment Center of Central New Jersey | East Windsor | New Jersey | |
| Dermatologists of Central States, LLC | Fairborn | Ohio | |
| Medical University of South Carolina | Charleston | South Carolina | |
| Texas Dermatology and Laser Specialists | San Antonio | Texas | |
| Medical College of Wisconsin | Milwaukee | Wisconsin | |
| CONEXA Investigacion Clinica S.A. | Buenos Aires | Argentina | |
| Instituto de Neumonología Y Dermatología | Buenos Aires | Argentina | |
| Derma Internacional | Buenos Aires | Argentina | |
| Psoriahue | Buenos Aires | Argentina | |
| Fundación Respirar | Buenos Aires | Argentina | |
| Fundacion Estudios Clinicos | Rosario | Argentina | |
| Cornerstone Dermatology | Coorparoo | Australia | |
| Sydney Children's Hospital | Randwick | Australia | |
| The Children's Hospital at Westmead | Westmead | Australia | |
| Veracity Clinical Research | Woolloongabba | Australia | |
| Fundação Pio XII - Hospital de Câncer de Barretos | Barretos | Brazil | |
| Centro de Pesquisa Sao Lucas | Campinas | Brazil | |
| Hospital de Clinicas de Porto Alegre | Porto Alegre | Brazil | |
| Hospital de Clínicas de Ribeirão Preto | Ribeirão Preto | Brazil | |
| IBPClin - Instituto Brasil de Pesquisa Clínica | Rio de Janeiro | Brazil | |
| Faculdade de Medicina do ABC | Santo André | Brazil | |
| Clinica de Alergia Martti Antila | Sorocaba | Brazil | |
| Dermatology Research Institute | Calgary | Canada | |
| DermEdge Research | Mississauga | Canada |
+ 45 more sites — see the full list on the official registry below.
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Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT05559359 on ClinicalTrials.gov ↗ ← All trials in Mexico