Early Use of Airway Pressure Release Ventilation (APRV) in ARDS

NCT04221737 · tracked via the Priya Life Science Mexico tracker

Sponsor

Hospital Civil de Guadalajara

Phase

Not applicable

Started

2017-07-15

Last updated

2026-09-17

Condition(s) studied

Acute Respiratory Distress Syndrome

Investigational drug(s) / intervention(s)

APRV. General Electric Healthcare Engstrom ventilator systemConventional. General Electric Healthcare Engstrom ventilator system

APRV. General Electric Healthcare Engstrom ventilator system: APRV consist of an extended time at plateau pressure (a continuous positive airway pressure phase) comprising about 90% of the respiratory cycle, while providing very brief releases to enhance carbon dioxide removal. Time-controlled adaptive method requires interpretation of the expiratory flow curve to assess changes in lung elastance and, therefore, set the Time low to optimize carbon dioxide removal, but not at the expense of alveolar derecruitment and instability.

Conventional. General Electric Healthcare Engstrom ventilator system: Lung protective ventilation consist of delivery of low tidal volumes (4-6 ml/kg PBW), high PEEP enough to avoid de-recruitment, titrated according to ARDSNet PEEP/fraction of inspired oxygen (FiO2) table, while avoiding excessive transpulmonary pressure.

Study summary

Airway pressure release ventilation (APRV) is a time-cycled, pressure controlled, intermittent mandatory ventilation mode with extreme inverse I:E ratios. Currently it is considered as a non-conventional ventilatory mode. The investigators aim to compare APRV with conventional mechanical ventilation (MV) in patients with acute respiratory distress syndrome (ARDS).

Eligibility

Sex

ALL

Min age

18 Years

Max age

80 Years

Healthy volunteers

Inclusion Criteria: * Acute respiratory distress syndrome, according to the Berlin definition of ARDS, with adjusted pO2/FiO2 for altitude \<300, and less than 48 h of endotracheal mechanical ventilation Exclusion Criteria: * Pregnancy * Less than 18 years-old * Expected duration of mechanical ventilation less than 48 h * Preexisting conditions with an expected 3-month mortality exceeding 50% * Concurrent chemotherapy * Confirmed intracranial hypertension * Catastrophic cranial trauma or neuromuscular disorders that are known to prolong mechanical ventilation * Pneumothorax at enrollment (resolved or not) * Do-not-resuscitate order

Primary outcome measure(s)

Mechanical ventilation free days — 28 days

Trial sites (1)

Facility	City	Region	Status
Hospital Civil Fray Antonio Alcalde	Guadalajara	Jalisco	Recruiting

More Hospital Civil de Guadalajara trials in Mexico

Reverse Trigger Phenotypification and Response to Ventilatory Adjustments Recruiting

Intestinal Preparation in Colonoscopy: Lactulose vs Sodium Phosphate. Recruiting

Evaluation of the Diaphragmatic Index Before and After a Pulmonary Rehabilitation Program in Patients With Interstitial Lung Diseases and Its Impact on Quality of Life Starting soon

Effects of Oral Stimulation Performed by Parents to Improve Sucking in Neonates Hospitalized in the NICU Recruiting

PD Catheter Survival: Modified Percutaneous vs Moncrief-Popovich Active, not recruiting

Other trials for the same condition

Reverse Trigger Phenotypification and Response to Ventilatory Adjustments Recruiting

Effect of Continuous Prolonged Prone Position Versus Intermittent Daily Prone Position in ARDS Recruiting

Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT04221737 on ClinicalTrials.gov ↗ ← All trials in Mexico