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Clinical Trials in Japan / NCT07252232
Recruiting Phase 3

Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)

NCT07252232 · tracked via the Priya Life Science Japan tracker
Sponsor
Revolution Medicines, Inc
Phase
Phase 3
Started
2025-12-15
Last updated
2026-09-23

Condition(s) studied

Pancreatic CancerPDACPDAC - Pancreatic Ductal AdenocarcinomaResectable Pancreatic Ductal Adenocarcinoma (PDAC)Resected Pancreatic Adenocarcinoma

Investigational drug(s) / intervention(s)

daraxonrasib →

daraxonrasib: oral tablets

Study summary

The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * At least 18 years old and has provided informed consent. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Histologically confirmed PDAC with successful (R0/R1) curative intent surgical resection and no evidence of recurrent or metastatic disease. * Must have received perioperative (neoadjuvant, adjuvant, or a combination of both) multi-agent chemotherapy. * Must have completed most recent treatment within the past 12 weeks. * Adequate organ function (bone marrow, liver, kidney, coagulation). * Documented RAS mutation status. * Able to take oral medications. Exclusion Criteria: * Prior therapy with direct RAS-targeted therapy (eg. degraders and/or inhibitors). * Any conditions that may affect the ability to take or absorb study drug. * Major surgery within 28 days prior to randomization. * Patient is unable or unwilling to comply with protocol-required study visits or procedures.

Primary outcome measure(s)

Trial sites (78)

FacilityCityRegionStatus
Mayo Clinic Phoenix Arizona Recruiting
HonorHealth Research Institute Scottsdale Arizona Recruiting
UC San Diego Moores Cancer Center La Jolla California Recruiting
Cedars-Sinai Cancer at Cedars-Sinai Medical Center Los Angeles California Recruiting
University of California, Los Angeles Los Angeles California Recruiting
Stanford Cancer Institute Palo Alto California Recruiting
University of California, Davis Comprehensive Cancer Center Sacramento California Recruiting
University of California, San Francisco San Francisco California Recruiting
Rocky Mountain Cancer Centers, LLP Lakewood Colorado Recruiting
Hartford Healthcare Hartford Connecticut Recruiting
Mayo Clinic Jacksonville Florida Recruiting
University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center Miami Florida Recruiting
Florida Cancer Specialists St. Petersburg Florida Recruiting
Piedmont Physicians Medical Oncology Atlanta Atlanta Georgia Recruiting
Winship Cancer Institute, Emory University Atlanta Georgia Recruiting
Community Health Network Indianapolis Indiana Recruiting
University of Kansas Medical Center Research Institute, Inc. Lawrence Kansas Recruiting
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital Baltimore Maryland Recruiting
Massachusetts General Hospital Boston Massachusetts Recruiting
Dana Farber Cancer Institute (DFCI) Boston Massachusetts Recruiting
Mayo Clinic Cancer Center Rochester Minnesota Recruiting
Saint Luke's Cancer Institute Kansas City Missouri Recruiting
University of Nebraska Medical Center Omaha Nebraska Recruiting
Comprehensive Cancer Centers of Nevada Las Vegas Nevada Recruiting
Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center New York New York Recruiting
Icahn School of Medicine at Mount Sinai New York New York Recruiting
Columbia University Medical Center New York New York Recruiting
Memorial Sloan Kettering Cancer Center New York New York Recruiting
University of Rochester Medical Center Rochester New York Recruiting
Duke Cancer Center Durham North Carolina Recruiting
Taylor Cancer Research Center Maumee Ohio Recruiting
University of Pennsylvania, Abramson Cancer Center Philadelphia Pennsylvania Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania Recruiting
Avera Cancer Institute Sioux Falls South Dakota Recruiting
SCRI Oncology Partners Nashville Tennessee Recruiting
Texas Oncology - DFW Dallas Texas Recruiting
University of Texas, Southwestern Medical Center Dallas Texas Recruiting
University of Texas MD Anderson Cancer Center Houston Texas Not Yet Recruiting
Texas Oncology - Northeast Texas Longview Texas Recruiting
University of Utah, Huntsman Cancer Institute Salt Lake City Utah Recruiting

+ 38 more sites — see the full list on the official registry below.

More Revolution Medicines, Inc. trials in Japan

Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) Active, not recruiting
Study of Daraxonrasib and Daraxonrasib + GnP as First-line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma Recruiting
Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301) Recruiting

Other trials for the same condition

A Study to Assess Intravenous (IV) Telisotuzumab Adizutecan in Combination With Fluorouracil, Folinic Acid, and Oxaliplatin (FOLFOX) Compared to Standard of Care in Adult Participants With First-Line Metastatic Pancreatic Ductal Adenocarcinoma Recruiting
Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor) Active, not recruiting
Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC) Active, not recruiting
A Study of Zolbetuximab (IMAB362) in Adults With Pancreatic Cancer Active, not recruiting
Multicenter Study of Circulating Tumor DNA in Patients With Pancreatic Cancer Using a Personalized Panel Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07252232 on ClinicalTrials.gov ↗ ← All trials in Japan