Clinical Trials in Japan / NCT07218341
Recruiting
Phase 4
A Study of Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT07218341 · tracked via the Priya Life Science Japan tracker
Condition(s) studied
Chronic Lymphocytic LeukemiaLymphoma, Small Lymphocytic
Investigational drug(s) / intervention(s)
Pirtobrutinib: Administered orally
Idelalisib: Administered orally
Study summary
This study will evaluate the long-term safety of pirtobrutinib in participants with previously treated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). The study is open to those who completed J2N-MC-JZNN/LOXO-BTK-20020 (NCT 04666038) for continued access to the study intervention or continued follow-up visits. Treatment will be given every 4 weeks and this study is expected to last about 5 years.
Eligibility
Inclusion Criteria:
* Are actively participating in study J2N-MC-JZNN/LOXO-BTK-20020
Exclusion Criteria:
* This is not applicable to this study
Primary outcome measure(s)
- Percentage of Participants with a Grade 3 or Higher Treatment-emergent Adverse Events (AEs) — Time from First Dose of Study Intervention (Study Day 1) through 30 Days After Last Dose of Study Intervention or Start of New Anticancer Therapy, whichever is Earlier
Trial sites (50)
| Facility | City | Region | Status |
|---|---|---|---|
| Mitchell Cancer Institute | Mobile | Alabama | Recruiting |
| Arizona Oncology Associates, P.C. - HOPE | Tucson | Arizona | Not Yet Recruiting |
| Cancer Specialists, LLC | Jacksonville | Florida | Recruiting |
| Minnesota Oncology Hematology, P.A. | Coon Rapids | Minnesota | Recruiting |
| Cayuga Cancer Center | Ithaca | New York | Not Yet Recruiting |
| Memorial Sloan-Kettering Cancer Center (MSKCC) - New York | New York | New York | Recruiting |
| Oncology Hematology Care Inc | Cincinnati | Ohio | Not Yet Recruiting |
| Texas Oncology - Paris | Fort Worth | Texas | Not Yet Recruiting |
| US Oncology - Texas Oncology | Kyle | Texas | Not Yet Recruiting |
| The Alfred Hospital | Melbourne | Australia | Not Yet Recruiting |
| LKH - Universitätsklinikum der PMU Salzburg | Salzburg | Austria | Not Yet Recruiting |
| AZ Delta | Roeselare | Belgium | Not Yet Recruiting |
| Princess Margaret Cancer Centre - University Health Network | Toronto | Canada | Not Yet Recruiting |
| Xuanwu Hospital Capital Medical University | Beijing | China | Not Yet Recruiting |
| Hunan Cancer Hospital | Changsha | China | Not Yet Recruiting |
| Sun Yat-sen University Cancer Center | Guangdong | China | Not Yet Recruiting |
| Nanfang Hospital of Southern Medical University | Guangzhou | China | Recruiting |
| Gansu Provincial Cancer Hospital | Lanzhou | China | Not Yet Recruiting |
| The First Affiliated Hospital of Nanchang University | Nanchang | China | Not Yet Recruiting |
| Fudan University Shanghai Cancer Center | Shanghai | China | Not Yet Recruiting |
| Taizhou Hospital of Zhejiang Province | Taizhou | China | Not Yet Recruiting |
| Hematology Hospital of the Chinese Academy of Medical Sciences | Tianjin | China | Recruiting |
| Tianjin Medical University Cancer Institute & Hospital | Tianjin | China | Not Yet Recruiting |
| Affiliated Cancer Hospital of Xinjiang Medical University | Ürümqi | China | Not Yet Recruiting |
| The Affiliated Hospital of Xuzhou Medical College | Xuzhou | China | Not Yet Recruiting |
| Henan Cancer Hospital | Zhengzhou | China | Not Yet Recruiting |
| University Hospital Center Zagreb | Zagreb | Croatia | Not Yet Recruiting |
| Fakultni nemocnice Hradec Kralove | Hradec Králové | Czechia | Not Yet Recruiting |
| Centre Henri Becquerel | Rouen | France | Not Yet Recruiting |
| Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet | Budapest | Hungary | Not Yet Recruiting |
| Debreceni Egyetem | Debrecen | Hungary | Not Yet Recruiting |
| St. James's Hospital | Dublin | Ireland | Not Yet Recruiting |
| Beaumont Hospital | Dublin | Ireland | Not Yet Recruiting |
| Tel Aviv Sourasky Medical Center | Tel Aviv | Israel | Not Yet Recruiting |
| Azienda Ospedaliero - Universitaria Nazionale Santi Antonio e Biagio e Cesare Arrigo | Alessandria | Italy | Not Yet Recruiting |
| Azienda Ospedaliera Universitaria Careggi | Florence | Italy | Not Yet Recruiting |
| Presidio Ospedaliero Papardo | Messina | Italy | Not Yet Recruiting |
| Fondazione IRCCS San Gerardo dei Tintori | Monza | Italy | Not Yet Recruiting |
| Azienda Ospedaliera di Perugia Ospedale S. Maria della Misericordia | Perugia | Italy | Not Yet Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Rome | Italy | Not Yet Recruiting |
+ 10 more sites — see the full list on the official registry below.
More Eli Lilly and Company trials in Japan
Other trials for the same condition
A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)
Active, not recruiting
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07218341 on ClinicalTrials.gov ↗ ← All trials in Japan