Selective Removal of Endometriotic Lesions Using CUSA Clarity in Ovarian Endometriomas

Condition(s) studied

Investigational drug(s) / intervention(s)

Cavitron Ultrasonic Surgical Aspirator (CUSA) Clarity: Ex vivo application of the Cavitron Ultrasonic Surgical Aspirator (CUSA) Clarity device to ovarian endometrioma cyst wall specimens. Tissue Select settings from 0 to 4 are used to evaluate tissue selectivity, specifically removal of endometriotic epithelium while preserving normal ovarian stroma. Samples are subsequently analyzed histopathologically.

Study summary

This study aims to evaluate the feasibility and tissue selectivity of a novel surgical technology, the Cavitron Ultrasonic Surgical Aspirator (CUSA) Clarity, in the management of ovarian endometriomas. Ovarian endometriomas are cysts caused by endometriosis that can damage ovarian reserve when treated by conventional surgery. In this study, ovarian cyst wall specimens are examined ex vivo using different Tissue Select settings of the CUSA device. Histopathological analyses are performed to determine whether endometriotic epithelium can be selectively removed while preserving normal ovarian tissue. The findings may contribute to developing fertility-preserving surgical approaches for women with endometriomas.

Eligibility

Primary outcome measure(s)

• Histopathological confirmation of selective removal of endometriotic epithelium with preservation of ovarian stroma — Immediately after ex vivo CUSA treatment of specimens (within 1 day of surgery)
  Evaluation of hematoxylin-eosin and immunohistochemical stained sections to determine whether endometriotic epithelial lining is removed while normal ovarian stroma is preserved.

Trial sites (1)

Other trials for the same condition