A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
Condition(s) studied
Investigational drug(s) / intervention(s)
LY4337713: Administered IV.
Study summary
This is a study of LY4337713 in participants with certain types of cancer that is advanced or has spread. Participants must have cancer with high levels of a protein called fibroblast activation protein (FAP). The purpose of this study is to evaluate safety, side effects, and efficacy of LY4337713. In addition, this study will evaluate how much LY4337713 gets into the bloodstream, how it is broken down, and how long it takes the body to get rid of it. For each participant, the study will last about 5 years.
Eligibility
Primary outcome measure(s)
- Phase 1a: Percentage of Participants with Dose Limited Toxicity (DLT) Toxicities — Cycle 1 (28 days)
- Phase 1b: Objective Response Rate (ORR): Percentage of Participants with Best Response of Complete Response (CR) or Partial Response (PR) — Baseline through imaging follow-up, up to 5 years
Per investigator assessed Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1)
Trial sites (30)
| Facility | City | Region | Status |
|---|---|---|---|
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | Recruiting |
| Stanford University Medical Center | Stanford | California | Recruiting |
| Biogenix Molecular, LLC | Miami | Florida | Completed |
| Moffitt | Tampa | Florida | Recruiting |
| Indiana University (IU) School of Medicine | Indianapolis | Indiana | Recruiting |
| United Theranostics | Glen Burnie | Maryland | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | Not Yet Recruiting |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | Recruiting |
| BAMF Health Inc. | Grand Rapids | Michigan | Recruiting |
| Mayo Clinic - Rochester | Rochester | Minnesota | Not Yet Recruiting |
| Washington University School of Medicine in St. Louis | St Louis | Missouri | Recruiting |
| New York University (NYU) Clinical Cancer Center | New York | New York | Recruiting |
| David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center | New York | New York | Recruiting |
| Duke University Medical Center | Durham | North Carolina | Recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | Recruiting |
| Texas Oncology - DFW (Sammons CC) | Dallas | Texas | Recruiting |
| Baylor College of Medicine | Houston | Texas | Not Yet Recruiting |
| University of Wisconsin - Carbone Cancer Center | Madison | Wisconsin | Recruiting |
| Zhongshan Hospital, Fudan University | Shanghai | China | Not Yet Recruiting |
| Universitaetsklinikum Essen | Essen | Germany | Not Yet Recruiting |
| National Cancer Center Hospital East | Chiba | Japan | Not Yet Recruiting |
| Kyoto University Hospital | Kyoto | Japan | Not Yet Recruiting |
| Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL) | Amsterdam | Netherlands | Not Yet Recruiting |
| Amsterdam UMC - Locatie VUmc | Amsterdam | Netherlands | Not Yet Recruiting |
| Erasmus MC | GE Rotterdam | Netherlands | Not Yet Recruiting |
| Maastricht University Medical Center | Maastricht | Netherlands | Not Yet Recruiting |
| Stichting Radboud Universitair Medisch Centrum | Nijmegen | Netherlands | Not Yet Recruiting |
| Universitair Medisch Centrum Utrecht | Utrecht | Netherlands | Not Yet Recruiting |
More Eli Lilly and Company trials in Japan
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07213791 on ClinicalTrials.gov ↗ ← All trials in Japan