Platelet-Rich Fibrin as an Antibiotic Delivery Vehicle in Mandibular Third Molar Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Antibiotic-enriched Platelet-Rich Fibrin (PRF): Platelet-rich fibrin prepared with the addition of antibiotic prior to centrifugation and applied into the mandibular third molar extraction socket to provide local antibiotic delivery.

Platelet-Rich Fibrin (PRF): Standard platelet-rich fibrin prepared without antibiotic addition and applied into the mandibular third molar extraction socket.

Study summary

The present study aims to evaluate the effect of platelet-rich fibrin (PRF) used as a local antibiotic delivery vehicle on postoperative outcomes, including facial swelling, trismus, and pain, following mandibular third molar surgery in a randomized split-mouth clinical trial.

Eligibility

Primary outcome measure(s)

• Incidence of postoperative infection — Up to 7 days after surgery
  Occurrence of postoperative infection following mandibular third molar surgery, assessed through clinical examination based on the presence of signs and symptoms of infection (e.g., purulent discharge, erythema, fever, or need for additional antibiotic therapy).
• Facial swelling qualitative analysis — Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
  Change in facial volume from baseline, assessed by three-dimensional facial scan superimposition and expressed as colorimetric variation between the preoperative and postoperative scans.
• Facial swelling quantitative analysis - volumetric differences — Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
  To compare postoperative facial swelling between treatment groups using quantitative three-dimensional analysis based on volumetric differences. Facial volume changes will be measured in cubic centimeters (cm³) through three-dimensional facial scan superimposition.
• Facial swelling quantitative analysis - linear differences — Change from baseline (before surgery) at 2 day after surgery and at 7 days after surgery
  To compare postoperative facial swelling between treatment groups using quantitative three-dimensional analysis based on linear measurements. Facial changes will be assessed by evaluating linear differences (mm) between preoperative and postoperative three-dimensional facial scans.

Trial sites (1)

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