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Clinical Trials in Italy / NCT07725770
Active, not recruiting Observational

Ten Years Follow-up After the Arthroscopic Repair of Osteochondral Lesions of the Talus Via Autologous Matrix-induced Chondrogenesis (AMIC)

NCT07725770 · tracked via the Priya Life Science Italy tracker
Sponsor
I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Phase
Observational
Started
2026-07-21
Last updated
2026-07-24

Condition(s) studied

Osteochondral Defect of Talus

Study summary

This clinical study evaluates the long-term, ten-year clinical and functional outcomes of patients who underwent arthroscopic repair of osteochondral lesions of the talus (OLT) using the autologous matrix-induced chondrogenesis (AMIC) technique. Conducted at the IRCCS Ospedale Galeazzi Sant'Ambrogio in Milan, the research addresses a critical gap in current medical literature. While the AMIC procedure is widely utilized to treat these challenging lesions, consolidated very long-term data at the ten-year mark remains scarce. Consequently, this study aims to verify whether the positive clinical benefits previously observed in the short and medium term remain stable over time or if they undergo a significant deterioration. The project will span a total duration of six months, analyzing a sample size of approximately 40 patients who received this specific treatment between April 2013 and April 2016.

Eligibility

Sex
ALL
Min age
—
Max age
—
Healthy volunteers
No
Inclusion Criteria: \- Patients who underwent repair of an osteochondral defect via the AMIC® procedure utilizing a porcine collagen I/III membrane (Chondro-Gide®). Exclusion Criteria: \- Irrelevant post-operative diagnoses (e.g., pigmented villonodular synovitis) or the inability to retrieve follow-up data.

Primary outcome measure(s)

  • Ten years follow-up after the arthroscopic repair of osteochondral lesions of the talus via autologous matrix-induced chondrogenesis (AMIC) — 10 years
    Clinical Outcomes (AOFAS - VAS)

Trial sites (1)

FacilityCityRegionStatus
IRCCS Ospedale Galeazzi-Sant'Ambrogio Milan Italy

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07725770 on ClinicalTrials.gov ↗ ← All trials in Italy