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Clinical Trials in Italy / NCT07563608
Recruiting Observational

Prevalence, Pathogenesis, and Prognosis of Pulmonary Hypertension in Dialysis Patients

NCT07563608 · tracked via the Priya Life Science Italy tracker
Sponsor
Fondazione IRCCS Policlinico San Matteo di Pavia
Phase
Observational
Started
2018-11-10
Last updated
2026-05-04

Condition(s) studied

Pulmonary Hypertension

Study summary

This prospective multicenter longitudinal study aims to investigate the prevalence, pathogenesis, and prognosis of pulmonary hypertension in patients with end-stage renal disease undergoing chronic hemodialysis. The research seeks to identify specific clinical factors and biomarkers like angiopoietin-2 that contribute to the development of this condition, while evaluating the prognostic value of right ventricular function measured via TAPSE. Participants undergo a standardized screening echocardiogram the day after their intermediate dialysis session to determine the probability of pulmonary hypertension. Those identified as high-risk receive further diagnostic confirmation through right heart catheterization, respiratory function tests, and lung scans to clarify the underlying etiology. The protocol also evaluates the hemodynamic impact of high-flow arteriovenous fistulas and volume overload on pulmonary pressures. Clinical follow-up is conducted at baseline and subsequently at 6, 12, and 24 months to monitor patient outcomes and standardize therapeutic management according to established European guidelines.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Patients aged between 18 and 75 years * Patients on stable extracorporeal hemodialysis for at least 6 months * Dialysis frequency of two or three times per week * Ability to provide written informed consent Exclusion Criteria: * WHO functional class IV * Presence of valvular or congenital heart disease * Acute infections within the month preceding the cardiological evaluation

Primary outcome measure(s)

  • Prevalence of pulmonary hypertension and its subtypes in patients undergoing chronic hemodialysis — Baseline (enrollment)

Trial sites (1)

FacilityCityRegionStatus
Fondazione IRCCS Policlinico San Matteo di Pavia Pavia Lombardy Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07563608 on ClinicalTrials.gov ↗ ← All trials in Italy