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Clinical Trials in Italy / NCT07499401
Recruiting Observational

Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational Study

NCT07499401 · tracked via the Priya Life Science Italy tracker
Sponsor
Università Politecnica delle Marche
Phase
Observational
Started
2024-12-15
Last updated
2026-04-02

Condition(s) studied

Venous CongestionMicrocirculationVolume Expansion

Investigational drug(s) / intervention(s)

fluid challenge →

fluid challenge: Signs of venous congestion and microcirculatory status will be assessed at baseline. A fluid challenge will then be performed, and microcirculation will be evaluated at the end of fluid administration and again after 30 minutes

Study summary

The hypothesis is that fluid-responsive patients who show signs of venous congestion experience a worsening of microcirculatory status after fluid administration compared to patients without signs of venous congestion

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Critically ill patients admitted to the intensive care unit * Invasive or minimally invasive hemodynamic monitoring Exclusion Criteria: * Suspected or confirmed pregnancy * Inability to access the oral cavity (e.g., facial trauma, oral bleeding)

Primary outcome measure(s)

  • Change in Sublingual total vessel density (TVD) — Baseline, immediately post-fluid challenge, and 30 minutes post-fluid challenge
    To compare changes in sublingual microcirculatory parameter - total vessel density (TVD) - before fluid administration, immediately after volume expansion, and 30 minutes post-fluid administration in preload-dependent patients with and without signs of venous congestion.

Trial sites (1)

FacilityCityRegionStatus
AOU delle Marche Ancona Italy Recruiting

More Università Politecnica delle Marche trials in Italy

Markers of Oxidative Stress in Inflammatory Bowel Diseases: Risk Factors and Implications for a Dietetic Approach Active, not recruiting
Assessment of Venous Return During Volume Expansion: a Prospective Observational Study Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07499401 on ClinicalTrials.gov ↗ ← All trials in Italy