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Clinical Trials in Italy / NCT07349966
Enrolling by invitation Observational

Effects of Trophectoderm (TE) Biopsy on the Health and Development of Children Born After Preimplantation Genetic Testing (PGT) Cycles.

NCT07349966 · tracked via the Priya Life Science Italy tracker
Sponsor
IRCCS San Raffaele
Phase
Observational
Started
2026-03-19
Last updated
2026-06-23

Condition(s) studied

Preimplantation Genetic Testing (PGT)Frozen Embryo Transfer CycleAssisted Reproduction TechnologiesPostnatal Health

Investigational drug(s) / intervention(s)

Questionnaire

Questionnaire: The only additional procedure involved in this study is the administration of a questionnaire to the parents, which is not part of routine clinical follow-up. The questionnaire was originally developed in the context of the Norwegian Mother and Child Cohort Study (MoBa).

Study summary

This study aims to investigate the effects of trophectoderm (TE) biopsy on the health and development of children born after preimplantation genetic testing (PGT) cycles. The blastocyst biopsy is performed as part of standard clinical practice, in accordance with established protocols and current national regulations governing assisted reproduction.

Eligibility

Sex
ALL
Min age
—
Max age
60 Months
Healthy volunteers
Accepted
Inclusion Criteria for Cases: * Child: Has completed the first year of life at the time of data collection. * Child: Does not have any pre-existing medical conditions that significantly affect growth (weight and height). * Mother: Able to provide informed consent for participation in the study. * Mother: Conceived between the ages of 18 and 43. * Mother: Achieved a singleton live birth with a single gestational sac. * Mother: Underwent a PGT cycle followed by FET. Inclusion Criteria for Controls: * Child: Has completed the first year of life at the time of data collection. * Child: Does not have any pre-existing medical conditions that significantly affect growth (weight and height). * Mother: Able to provide informed consent for participation in the study. * Mother: Conceived between the ages of 18 and 43. * Mother: Achieved a singleton live birth with a single gestational sac. * Mother: Underwent only FET. Participants will be excluded from this study if they meet any of the following criteria: * Mother: Unable or unwilling to sign the informed consent. * Mother: Has undergone a fresh embryo transfer. * Child: Missing birth weight or length/height data.

Primary outcome measure(s)

  • Impact of Blastocyst Biopsy on Postnatal Growth at One Year — 12 months of life of children
    Questionnaire

Trial sites (1)

FacilityCityRegionStatus
Irccs San Raffaele Hospital Milan Milano

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07349966 on ClinicalTrials.gov ↗ ← All trials in Italy