Effects of Dexmedetomidine Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Dexmedetomidine Target Controlled infusion (TCI, Dyck model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol and Remifentanil TCI (Eleveld model) has not been investigate yet.
Authors aim to investigate its effect on Patient State index (PSi), the power spectrum EEG, the Analgesia Nociception Index (ANI) and pupillometry values during maintenance during TIVA-TCI with Propofol, Remifentanil and Dexmedetomidine.
Eligibility
Sex
FEMALE
Min age
18 Years
Max age
80 Years
Healthy volunteers
No
Inclusion Criteria:
* Undergo general anaesthesia with Targeted Controlled Infusion of Propofol and Rmifntanil (Eleveld model) and Dexmedetomidine (Dyck model)
Exclusion Criteria:
* Neurological disease
* Psychiatric disease
* Obesity
* Regional anesthesia performed
Primary outcome measure(s)
Effects of Dexmedetomidine on Patient State index (PSi) during stable Propofol - Remifentanil general anesthesia — PSi values and DexmedetomidineTarget Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery Evaluate if Dexmedetomidine variations during general anesthesia has an impact on the PSi values
Effects of Dexmedetomidine on Electroencephalogram (EEG) power spectrum during stable Propofol - remifentanil general anesthesia — EEG power spectrum and DexmedetomidineTarget Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery Evaluate if dexmedetomidine variations during general anesthesia has an impact on the EEG power spectrum
Effects of Dexmedetomidine on Analgesia Nociception Index (ANI) during stable Propofol general anesthesia — ANI values and Sufentanil Target Controlled Infusion (TCI) concentrations will be monitored during all the time of surgery Evaluate if dxmedetomidine variations during general anesthesia has an impact on the ANI values
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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