Electroencephalogram in Patients With Friedreich's Ataxia for the Study of the Structural and Functional Connectome.

Condition(s) studied

Investigational drug(s) / intervention(s)

HD-EEG recordings, combined with cognitive and motor assessment: Participants will undergo high-density EEG (HD-EEG) recordings under two conditions: at rest and while performing an upper limb motor task. The data obtained will be used to reconstruct source cortical activity and derive patterns of functional connectivity, using advanced neurophysiological analysis techniques, including the Avalanche Transition Matrix (ATM). In addition, patients will complete a neuropsychological assessment and participate in an intensive multidisciplinary rehabilitation program lasting 3 to 4 weeks, depending on age. The intervention aims to assess changes in the functional organization of the brain before and after treatment, as well as one year later, in order to explore potential biomarkers of disease progression.

Study summary

Prospective, exploratory, multicenter pilot study investigating the structural and functional connectome in patients with Friedreich's Ataxia (FRDA) using high-density electroencephalogram (HD-EEG). The aim is to identify neurophysiological biomarkers and analyze the relationship between cortical connectivity, cognitive functioning, and clinical severity, particularly in response to rehabilitation treatment.

Eligibility

Primary outcome measure(s)

• Connectivity profile derived from HD-EEG in subjects with FRDA. — From enrollment to the end of treatment at 3 to 4 weeks and after 1 year of follow-up
  Characterization of alterations in the connectome derived from the HD-EEG of subjects with FRDA compared with matched controls;
• Functional activity derived from HD-EEG in subjects with FRDA. — From enrollment to the end of treatment at 3 to 4 weeks and after 1 year of follow-up
  Evaluation of functional connectivity as a biomarker in the evolution of FRDA

Trial sites (1)

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