Clinical Trials in Italy / NCT06947993
Recruiting
Phase 2
Platform Study to Evaluate the Efficacy and Safety of Investigational Compound(s) in Patients With Moderate to Severe Atopic Dermatitis
NCT06947993 · tracked via the Priya Life Science Italy tracker
Condition(s) studied
Atopic Dermatitis
Investigational drug(s) / intervention(s)
GHZ339Placebo
GHZ339: GHZ339 administered at dose A, B, C and D
Placebo: Matching placebo
Study summary
This trial is designed to evaluate multiple compounds in participants with moderate to severe atopic dermatitis (AD).
Eligibility
Key Inclusion Criteria of the master protocol:
* Able and willing to sign the informed consent (IC)
* Patients with a diagnosis of AD and onset of disease for at least 1 year
* Moderate to severe AD
Key Exclusion Criteria of the master protocol:
* Participants with a clinically significant medical condition or infectious disease (specified in sub-protocol)
* Participants with clinically significant abnormal hematology, clinical chemistry, or urine test results or clinically significant abnormal ECG
* Participant with any other active inflammatory skin disease
* Participants with any chronic, uncontrolled medical condition, which would put the participant at increased risk during the study (e.g., uncontrolled: diabetes, hypertension)
* Participants with any clinically unstable disease states that would likely require systemic corticosteroids (e.g., uncontrolled asthma)
Additional inclusion and exclusion criteria may apply depending on the intervention specific requirements
Primary outcome measure(s)
- Change from baseline in the Eczema Area and Severity Index (EASI) score at Week 16 — Baseline, Week 16
EASI will be used to assess the extend and severity of atopic dermatitis on a scale from 0 to 72 where 72 is worst eczema.
Trial sites (105)
| Facility | City | Region | Status |
|---|---|---|---|
| Novartis Investigative Site | Birmingham | Alabama | Recruiting |
| Novartis Investigative Site | Birmingham | Alabama | Recruiting |
| Novartis Investigative Site | Fort Smith | Arkansas | Recruiting |
| Novartis Investigative Site | Fountain Valley | California | Recruiting |
| Novartis Investigative Site | Los Angeles | California | Recruiting |
| Novartis Investigative Site | Sacramento | California | Recruiting |
| Novartis Investigative Site | Santa Ana | California | Recruiting |
| Novartis Investigative Site | Santa Monica | California | Recruiting |
| Novartis Investigative Site | Washington D.C. | District of Columbia | Recruiting |
| Novartis Investigative Site | Miami | Florida | Recruiting |
| Novartis Investigative Site | St. Petersburg | Florida | Recruiting |
| Novartis Investigative Site | Atlanta | Georgia | Recruiting |
| Novartis Investigative Site | Macon | Georgia | Recruiting |
| Novartis Investigative Site | Louisville | Kentucky | Recruiting |
| Novartis Investigative Site | Brighton | Massachusetts | Recruiting |
| Novartis Investigative Site | Troy | Michigan | Recruiting |
| Novartis Investigative Site | Saint Joseph | Missouri | Recruiting |
| Novartis Investigative Site | Portsmouth | New Hampshire | Recruiting |
| Novartis Investigative Site | Brooklyn | New York | Recruiting |
| Novartis Investigative Site | Arlington | Texas | Recruiting |
| Novartis Investigative Site | Cypress | Texas | Recruiting |
| Novartis Investigative Site | Dallas | Texas | Recruiting |
| Novartis Investigative Site | Houston | Texas | Recruiting |
| Novartis Investigative Site | San Antonio | Texas | Recruiting |
| Novartis Investigative Site | Caba | Buenos Aires | Recruiting |
| Novartis Investigative Site | Caba | Buenos Aires | Recruiting |
| Novartis Investigative Site | Rosario | Santa Fe Province | Recruiting |
| Novartis Investigative Site | Edmonton | Alberta | Active Not Recruiting |
| Novartis Investigative Site | Hamilton | Ontario | Recruiting |
| Novartis Investigative Site | Markham | Ontario | Recruiting |
| Novartis Investigative Site | Montreal | Quebec | Recruiting |
| Novartis Investigative Site | Verdun | Quebec | Active Not Recruiting |
| Novartis Investigative Site | Guangzhou | Guangdong | Active Not Recruiting |
| Novartis Investigative Site | Shantou | Guangdong | Active Not Recruiting |
| Novartis Investigative Site | Changsha | Hunan | Active Not Recruiting |
| Novartis Investigative Site | Changchun | Jilin | Active Not Recruiting |
| Novartis Investigative Site | Hangzhou | Zhejiang | Recruiting |
| Novartis Investigative Site | Beijing | China | Withdrawn |
| Novartis Investigative Site | Beijing | China | Active Not Recruiting |
| Novartis Investigative Site | Shanghai | China | Recruiting |
+ 65 more sites — see the full list on the official registry below.
More Novartis Pharmaceuticals trials in Italy
Phase 3 Study of Pelabresib (CPI-0610) in Myelofibrosis (MF) (MANIFEST-2)
Active, not recruiting
Study of PIT565 in Relapsed and/or Refractory B-cell Malignancies
Active, not recruiting
Other trials for the same condition
A Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe Atopic Dermatitis
Active, not recruiting
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06947993 on ClinicalTrials.gov ↗ ← All trials in Italy