Tissue Markers Predictive of Early Stenosis in the Arterovenous Fistula for Hemodialysis

Condition(s) studied

Investigational drug(s) / intervention(s)

Identification any tissue markers predictive or favoring early stenosis in AVF for haemodialysis.: Primary objective 1. Identify any predictive or favoring tissue markers of early stenosis in AVF for hemodialysis. Secondary objectives 2. Compare the results on the possible different expression of tissue markers before and during dialysis. 3. Compare the results on the possible different expression of tissue markers between AVFs made with portions of cephalic vein and AVFs made with portions of basilic vein, in order to evaluate whether the different topographic origin of the AVF can influence its duration.

Study summary

The study involves the recruitment of two populations. POPULATION 1 (surgical sample of excess venous segment): at least 75 consecutive patients, enrolled according to the inclusion criteria and subjected to first AVF surgery as part of the normal care pathway, at the Metropolitan Vascular Surgery Unit, Dir. Prof. Mauro Gargiulo of the S.Orsola-Malpighi University Hospital.

POPULATION 2 (surgical sample of arterialized venous segment from removal of previous AVF): at least 75 consecutive patients, enrolled according to the inclusion criteria and subjected to reoperation for correction of complication and/or new AVF by proximalization, as part of the normal care pathway, at the Metropolitan Vascular Surgery Unit, Dir. Prof. Mauro Gargiulo of the S.Orsola-Malpighi University Hospital.

Eligibility

Primary outcome measure(s)

• Identify any predictive or favoring tissue markers of early stenosis in AVF for hemodialysis. — From the first patient entrolled, up to the 150th patient, an average of 6 years
  Biomarkers of the treated fistula are histologically examined

Trial sites (1)

More IRCCS Azienda Ospedaliero-Universitaria di Bologna trials in Italy