Ireland
--:--IST
Latest
Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide Astellas Expands Its 330 Million Euro Tralee Biopharma Facility with a Second Aseptic Filling Line to Double Drug-Product Capacity Xeolas Pharmaceuticals Opens 158,000 Sq Ft State-of-the-Art Baldoyle Facility to Scale Specialty Medicine Manufacturing Priya Life Science Partners with Fleming for the 9th Annual Corporate Compliance & Transparency in Life Sciences Summit in Zurich Ireland Has the Capital and the Lessons: Digital Project Management Is How They Become Delivery Dunbar Pharma Brings First Plant-Derived Dronabinol API to UK Market Through IPS Pharma Leveraging Priya Life Science as a Data Tracker: The Ultimate Use Case & Career Guide
Clinical Trials in Italy / NCT06497855
Recruiting Observational

Impact of Estimated Concentration of Propofol on Implicit Memory Formation

NCT06497855 · tracked via the Priya Life Science Italy tracker
Sponsor
University of Padova
Phase
Observational
Started
2024-07-01
Last updated
2026-06-08

Condition(s) studied

General AnaesthesiaImplicit Memory

Study summary

Implicit memory formation and learning during general anaesthesia is a still debated question and no anesthetic regimen (ie intravenous anaesthesia vs inhalatory one) nor analgesic regimen (i.e. low or high opioids usage) has been identified for prevention.

With this study the investigators aim to investigate if, during Total Intravenous Anaesthesia with Target Controlled Infusion (TIVA-TCI) different concentrations of Propofol at loss of responsiveness, maintenance and return of responsiveness can have a role in implicit memory formation.

Eligibility

Sex
FEMALE
Min age
18 Years
Max age
90 Years
Healthy volunteers
No
Inclusion Criteria: * General anaesthesia with TIVA-TCI Exclusion Criteria: * ASA \> III * Benzodiazepines premedication * Neurological/Psychiatric disease

Primary outcome measure(s)

  • The role of Propofol Concentration at the loss of responsiveness on Implicit Memory formation — CeP will be recorded at Loss of responsiveness. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.
    CeP at LOR will be compared between patients who exhibit or not implicit memory formation.
  • The role of Propofol Concentration at the maintenance of anaesthesia on Implicit Memory formation — CeP will be recorded during anaesthesia maintenance. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.
    CeP at anaesthesia maintenance will be compared between patients who exhibit or not implicit memory formation.
  • The role of Propofol Concentration at the return of responsiveness on Implicit Memory formation — CeP will be recorded at Return of responsiveness. Word Steam recognition, Free recall and Forced Choice Recognition Task will be performed within 12-24 hours after surgery. These 3 tests are analysed togheter to check for implicit memory formation.
    CeP at ROR will be compared between patients who exhibit or not implicit memory formation.

Trial sites (1)

FacilityCityRegionStatus
Treviso Regional Hospital Treviso TV Recruiting

More University of Padova trials in Italy

Electrical Activity of the Diaphragm and Respiratory Mechanics During NAVA Recruiting
Evaluation of ProLife 10 FORTE on Gut Microbiota Composition in UC Patients Recruiting
Preoperative TAP Block Versus Postoperative TAP Block in Patients Undergoing Laparoscopic Cholecystectomy: a Randomized Controlled Trial Recruiting
Educational Interventions in Venous Leg Ulcer Starting soon
Evaluation of the Effects of Colipral on Microbiota Gut Composition in Patients Presenting With Ulcerative Colitis During Remission Phase and Functional Disorders Starting soon
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06497855 on ClinicalTrials.gov ↗ ← All trials in Italy