Changes in the Lipidomic, Immunological and miRNA Profile in Patients Undergoing a Dietary Program or Bariatric Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Nutritional Approach: Nutritional Approach

Surgery Approach: Bariatric surgery

Study summary

Obesity is a chronic disease characterized phenotypically by an increase in body weight (BMI\>30 kg/m2) and by a series of associated pathologies, such as hypertension, diabetes, hepatic steatosis.

The association of these pathologies compromises the patient's survival and quality of life. The multifactorial origin of obesity makes its etiopathology difficult to manage. It is often possible to follow only one therapeutic strategy, especially after the so-called standard treatments, such as dietary intervention and physical activity, have not brought benefit to the patient. In these cases, an appropriate treatment for the patient to enjoy significant weight loss is bariatric surgery.

Bariatric surgery refers to all those interventions aimed at reducing weight in those suffering from obesity, and treating the diseases associated with it.

Among the different types of bariatric surgery, the techniques most used in common clinical practice are intragastric balloons, gastric by pass (RYGB) and sleeve gastrectomy.

The choice of the surgeon, assisted by the multidisciplinary team, is binding in the choice of the type of operation to which the patient will be subjected.

Eligibility

Primary outcome measure(s)

• Variation of lipidomic parameters — at Baseline and at 1 year
  Variation of lipidomic parameters measured by extraction of fatty acids from red blood cells and run in gas chromatography
• The effect of intervention on routine blood chemistry parameters, relating to NAFLD and fibrosis — at Baseline and at 1 year
  Evaluate how bariatric surgery affects routine blood chemistry parameters. The following will be taken into consideration: Blood sugar, Glycated hemoglobin, triglycerides, total cholesterol, HDL and LDL, transaminases, γGT, creatinine, uric acid
• Variation in the microRNA profile — at Baseline and at 1 year
  Evaluation of microRNA profile change by real-time PCR

Trial sites (1)

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