A single-center, randomized trial will be conducted in order to compare three Endoscopic Gastroplasty (EG) techniques in obese patients (BMI 30-44.99 kg/m2) at Gastroenterology and Gastrointestinal Endoscopy Unit, Mater Olbia Hospital, Qatar Foundation Endowment \& Gemelli Foundation, Italy in period June 2020 - August 2024, with the aim to compare the efficacy and safety of these procedures.
Eligibility
Sex
ALL
Min age
18 Years
Max age
70 Years
Healthy volunteers
No
Inclusion Criteria:
* age \> 18 years old;
* acceptance of written informed consent to undergo an EG;
* capability to understand and comply with the study protocol;
* obesity: a BMI of 30-34.99 kg/m2 with previous failed attempts at diet and with obesity-related diseases, a BMI of 35-39.99 kg/m2 with previous failed attempts at diet and with or without obesity-related diseases, a BMI of 40-44.99 kg/m2 with previous failed attempts at diet and with or without obesity-related diseases not fit for surgery.
Exclusion Criteria:
* patients who do not give their consent to the enrollment in the study or are incompetent, unconscious or unable to express their consent for any reason;
* patients suffering from any condition which precludes compliance with study instructions;
* patients who underwent previous attempts at surgical or endoscopic bariatric therapy;
* patient has any allergy or other known contraindication or intolerance to the medications used in the study;
* women who are either pregnant or nursing at the time of screening, or are of child-bearing potential and do not practice methods of contraception;
* patient suffers from a life threatening condition.
Primary outcome measure(s)
Percentage of Total Body Weight Loss (TBWL percent) — at 30±15, 90±30, 180±30, 360±30, 540±30 days after the procedure To evaluate the percentage of Total Body Weight Loss after each endoscopic bariatric procedure
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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