Clinical Trials in Italy / NCT06156774
Recruiting
Observational
SARcopenia and Simplified Geriatric Assessment in Lymphoma Patients Undergoing CAR-T Cell Therapy: the FIL_SAR-CAR Project
NCT06156774 · tracked via the Priya Life Science Italy tracker
Condition(s) studied
Non-hodgkin Lymphoma,B Cell
Investigational drug(s) / intervention(s)
Chimeric Antigen Receptor T-cells (CAR-T) therapy
Chimeric Antigen Receptor T-cells (CAR-T) therapy: Patients will be treated with CAR-T cell product as per routine clinical practice.
Study summary
This is a multicenter prospective observational study lead by the FIL on sarcopenia and sGA as possible predictors of efficacy and toxicity outcomes in patients undergoing CAR-T cells treatment.
Eligibility
Inclusion Criteria:
* Adult patients (≥ 18 years old).
* Patients with B-cell non-Hodgkin Lymphoma scheduled to received CAR-T cell product according to Agenzia Italiana del Farmaco (AIFA) indications and technical data sheet of the drug
* Availability of a 18F-FDG PET/CT scan or a full dose CT scan (without contrast media) pre-treatment with CART
* Written informed consent voluntarily provided
Exclusion Criteria:
* Patients not fulfilling the eligibility criteria
Primary outcome measure(s)
- Best Overall Response Rates (ORR) — up to 28 months
Best Overall Response Rates (ORR) after CAR-T therapy according to the presence or absence of sarcopenic status
Trial sites (21)
| Facility | City | Region | Status |
|---|---|---|---|
| A.O. SS. Antonio e Biagio e Cesare Arrigo - S.C.D.U. Ematologia | Alessandria | Italy | Recruiting |
| AOU Ospedali Riuniti - Clinica di Ematologia | Ancona | Italy | Recruiting |
| Azienda Ospedaliera S .Giuseppe Moscati - S.C. Ematologia e Trapianto emopoietico | Avellino | Italy | Recruiting |
| IRCCS Centro di Riferimento Oncologico di Aviano - Divisione di Oncologia e dei Tumori immuto-correlati | Aviano | Italy | Recruiting |
| ASST Spedali Civili di Brescia - S.C. Ematologia | Brescia | Italy | Recruiting |
| Ospedale di Castelfranco Veneto - Oncoematologia IOV | Castelfranco Veneto | Italy | Recruiting |
| Azienda Ospedaliera Universitaria Careggi - Unità funzionale di Ematologia | Florence | Italy | Recruiting |
| ASST Grande Ospedale Metropolitano Niguarda - S.C. Ematologia | Milan | Italy | Recruiting |
| Fondazione IRCCS Istituto Nazionale dei Tumori di Milano - Ematologia | Milan | Italy | Recruiting |
| Istituto Scientifico San Raffaele - Unità Linfomi - Dipartimento Oncoematologia | Milan | Italy | Recruiting |
| A.O. Ospedali Riuniti Villa Sofia-Cervello - Divisione di Ematologia | Palermo | Italy | Recruiting |
| Ospedale S. Maria della Misericordia - Ematologia | Perugia | Italy | Recruiting |
| Ospedale Guglielmo da Saliceto - U.O. Ematologia | Piacenza | Italy | Recruiting |
| AOU Pisana - U.O. Ematologia | Pisa | Italy | Not Yet Recruiting |
| Azienda Unità Sanitaria Locale-IRCCS - Arcispedale Santa Maria Nuova - Ematologia | Reggio Emilia | Italy | Recruiting |
| Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica S. Cuore - Ematologia | Roma | Italy | Recruiting |
| Policlinico Umberto I - Università "La Sapienza" - Istituto Ematologia -Dipartimento di Medicina Traslazionale e di Precisione | Roma | Italy | Recruiting |
| A.O.U. Citta della Salute e della Scienza di Torino - S.C. Ematologia | Torino | Italy | Recruiting |
| Azienda Sanitaria Universitaria Friuli Centrale (ASU FC) - Clinica di Ematologia | Udine | Italy | Recruiting |
| AOU Integrata di Verona - U.O. Ematologia | Verona | Italy | Recruiting |
| ULSS 8 Berica - Ospedale S. Bortolo - Ematologia | Vicenza | Italy | Recruiting |
More Fondazione Italiana Linfomi - ETS trials in Italy
Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06156774 on ClinicalTrials.gov ↗ ← All trials in Italy