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Recruiting Observational

Detection and Prevention of Cancer-Related Cardiovascular Toxicity Registry

NCT06086132 · tracked via the Priya Life Science Italy tracker
Phase
Observational
Started
2025-05-01
Last updated
2025-06-19

Condition(s) studied

Cancer Related Cardiovascular Toxicity

Investigational drug(s) / intervention(s)

Prospective validation of the HFA-ICOS risk score in a subset of subjects with newly diagnosed breast cancer and undergoing treatment with anthracyclines analogues with or without radiotherapy

Prospective validation of the HFA-ICOS risk score in a subset of subjects with newly diagnosed breast cancer and undergoing treatment with anthracyclines analogues with or without radiotherapy: Follow-up visits at baseline, 3-months, and 1-year

Study summary

This study is being done in order to assess the cardiovascular events known as cardiovascular toxicity of chemotherapy agents and radiotherapy protocols in cancer subjects to identify risk prediction, prevention and treatment of cancer therapy-related cardiovascular toxicity and cancer therapy-related cardiac dysfunction

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Age 18 years old or older * Capable of giving informed consent * Diagnosis of cancer scheduled for treatment according to treating physician's discretion * Life expectancy \>1 year * For the prospective validation of HFA-ICOS risk score validation: Newly diagnosed breast cancer undergoing treatment with anthracyclines analogues with or without radiotherapy, with or without trastuzumab, or other anticancer drugs Exclusion Criteria: * Age \<18 years old * Not able to give informed consent * Life expectancy \<1 year * Advanced-stage cancer not eligible for treatment (subjects with an indication of palliative care) according to treating physician's

Primary outcome measure(s)

  • All causes mortality — For approximately a median of 3 years
    Occurrence of all cause death
  • Cardiovascular mortality — For approximately a median of 3 years
    Occurrence of cardiovascular mortality
  • Cancer therapy-related cardiovascular toxicity — For approximately a median of 3 years
    Occurrence of cancer therapy-related cardiovascular toxicity

Trial sites (5)

FacilityCityRegionStatus
University of Bologna Bologna Italy Not Yet Recruiting
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" Palermo Italy Not Yet Recruiting
Ss. Cyril and Methodius University in Skopje, University Clinic Skopje North Macedonia Recruiting
University of Belgrade, Clinical Center of Serbia Belgrade Serbia Recruiting
University of Belgrade, Clinical Hospital Center Bezanijska kosa Belgrade Serbia Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06086132 on ClinicalTrials.gov ↗ ← All trials in Italy