Predicting Cerebrovascular Adverse Events Post Cardiac Surgery

Condition(s) studied

Investigational drug(s) / intervention(s)

Cerebral autoregulation monitoring: Perioperative characterization of cerebral autoregulation and autonomic function; characterization of adverse events after surgery

Study summary

The aims of this study are: i) to assess cerebral autoregulation and autonomic control within the different phases of cardiac surgery with cardiopulmonary bypass; ii) to compare cerebral autoregulation measures derived via cerebral blood flow velocity estimated by transcranial Doppler device with simpler measurements derived from near infrared spectroscopy; iii) to develop a predictive model of postoperative cerebrovascular outcome (overt or silent stroke) based on the extracted indices.

Eligibility

Primary outcome measure(s)

• Autoregulation index (ARI) — 36 months
  ARI is an index describing the state of cerebral autoregulation from mean cerebral blood velocity and mean arterial pressure. It ranges between 1 and 9. ARI\>4 means working autoregulation. ARI\<4 means impaired autoregulation. It will be computed for all participants in BASAL, ANESTH, CPB.
• Cerebral Oxymetry index (CoX) — 36 months
  CoX is an index describing the state of cerebral autoregulation derived from NIRS and mean arterial pressure. It ranges between 0 and 1. CoX = 1 means perfect coupling. Cox=0 means uncoupling. It will be computed for all participants in BASAL, ANESTH, CPBasurements derived from near infrared spectroscopy
• number of patients developing cerebrovascular adverse events — 36 months
  The number of patients developing cerebrovascular adverse events will be assessed by the presence of positive lesions as detected by DW-MRI.

Trial sites (1)

More IRCCS Policlinico S. Donato trials in Italy

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