Metabolic Profile of Bone in Professional Athletes

Condition(s) studied

Investigational drug(s) / intervention(s)

blood and saliva tests: Blood and saliva will be tested for: bone turnover markers, cytokines, chemokines, adipokines, myokines and hormones regulating bone and energy metabolism

Study summary

Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and/or impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the production of several mediators and effectors that have systemic effects). However, different kinds of physical activity exert different effects on bone and endocrine system.

Aim of the study is to investigate the effects of different kinds of physical activity on bone metabolism and on the relationships existing between bone metabolism, energy metabolism, hormone profile, and organ functionality.

Eligibility

Primary outcome measure(s)

• Bone turnover markers — 0-36 Months
  different markers of bone turnover (osteocalcin, N-terminal type I pro-collagen, beta-crosslaps, osteopontin, bone-alkaline phosphatase, tartrate-resistant acid phosphatase 5b) will be tested depending on the group of subjects considered time-by-time

Trial sites (1)

More I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio trials in Italy

Other trials for the same condition