The ISAR InflEx Trial (Inflammation and Exercise)

Condition(s) studied

Investigational drug(s) / intervention(s)

moderate-intensity exercise: Guideline recommended 150 min/week of moderate-intensity aerobic physical exercise (40-50% VO2peak) on 5 days per week (30 min per session)

vigorous-intensity exercise: Guideline recommended 75 min/week of vigorous-intensity physical exercise (70-80% VO2peak) on 5 days per week (15 min per session)

short bouts of maximal exercise: Maximal vigorous-intensity physical exercise for 1 minute twice per day (\>90% VO2peak) on 5 days per week (1 min per session, total of 2 min per day)

Study summary

A sedentary lifestyle and obesity are associated with chronic low-grade inflammation and an elevated risk of cardiovascular disease (CVD). This study aims to systematically characterize and compare the effects of three distinct exercise modalities - moderate-intensity, vigorous-intensity, and short-duration maximal exercise - each differing in duration and intensity, on systemic inflammation and immune function. The study investigates the potential of exercise as an effective anti-inflammatory intervention for the prevention of CVD.

Eligibility

Primary outcome measure(s)

• Changes in blood leukocyte levels pre- and post-intervention — From enrollment to the end of the last intervention at 15 weeks

Trial sites (1)

Other trials for the same condition