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Clinical Trials in France / NCT07831733
Starting soon Not applicable

Study on the Prevention of Weight Loss Through Physical Activity Among Nursing Home Residents

NCT07831733 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Toulouse
Phase
Not applicable
Started
2026-09-01
Last updated
2026-09-21

Condition(s) studied

Appetite Loss in AgingAnorexia of Aging

Investigational drug(s) / intervention(s)

Physical activityAppetite assessmentFood intake assessmentAssessment of the efficiencyBlood test at baselineBlood test at the end of the studyFunctional capacities assessmentweight measurment

Physical activity: The participants will partake in physical activity sessions twice a week for about 45-60 minutes each which will consist of exercises designed to improve mobility, motor skills, balance, strength and muscular endurance, as well as the cardiorespiratory system. All exercises will be tailored to each person's abilities and can be performed while sitting or standing.

Appetite assessment: The appetite will be evaluated by a self-assessment questionnaire SNAQ.

Food intake assessment: It will be assessed by the healthcare team of the patient at baseline and at the end of the study.

Assessment of the efficiency: It will be evaluated by a self-assessment questionnaire EQ-5D-5L.

Blood test at baseline: A blood test will be done at the beginning of the study to evaluate the blood concentrations of leptin, insulin and GDF-15.

Blood test at the end of the study: It will be done at the end of the study (month 6) to evaluate the changes in blood concentrations of leptin, insulin and GDF-15.

Functional capacities assessment: The functional capacities will be assessed by : * Mini-Mental State Examination (MMSE) for cognition * Mini Nutritional Assessment (MNA) short form for nutrition * Whisper test for hearing * step-1 ICOPE question for vision * Short Physical Performance Battery (SPPB) and grip strength for mobility * Montgomery-Åsberg Depression Rating Scale (MADRS) and PHQ-2 for mood

weight measurment: the weight will be measured every month (kilogramm).

Study summary

Appetite loss is frequent in institutionalized older adults. Physical activity is known for its benefits on appetite regulation but its effects in nursing home residents remain poorly investigated. This project will investigate the 6-month longitudinal relationships between daily physical activity time with appetite and bodyweight and how engaging in a 6-month regular exercise program can improve theses outcomes in older institutionalized older adults.

Eligibility

Sex
ALL
Min age
65 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: For both the observational and interventional parts: * Be a resident in a nursing home (EHPAD). * Be affiliated with the social security system. * Be aged 65 years or older. * Have a GIR score \> 2. * Be able to walk 4 meters (with a walking aid if necessary, but without human assistance). * Provide written consent For the interventional part only: \- Be able to understand instructions for performing the exercises. Exclusion Criteria: For both the observational and interventional parts: * Unstable cardiovascular disease or any other health condition contraindicating physical exercise. * End-of-life situation identified in the medical record. * Planned relocation to another facility during the 6-month follow-up period. * To be under legal protection or guardianship

Primary outcome measure(s)

  • Changes in bodyweight — 6 months
    It will be assessed by measuring the bodyweight (kg) seven times (initially and once a month). For the observational arm, it will be measured based on daily physical activity (min/day) as measured by activity trackers. For the interventional arm, it will be measured based on participation in the physical activity program (ratio of sessions attended to sessions scheduled) over a 6-months period.

Trial sites (1)

FacilityCityRegionStatus
University Hospital Toulouse France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07831733 on ClinicalTrials.gov ↗ ← All trials in France