Creation of a Biological Collection of BRonchiaI and Pulmonary Tissues From Surgical wastE

Condition(s) studied

Investigational drug(s) / intervention(s)

Fiberscopic samples: Perform brushing and/or bronchial biopsies and/or BAL and/or aspiration during bronchial fiberscopy and surgical waste during a lobectomy.

Sputum: Sputum has been collected for biological analysis.

Nasal brushing: Nasal brushing is a minimally invasive medical procedure used to collect cellular samples from the nasal lining by gently rubbing a small cytology brush against the mucosa.

blood sampling: Blood sampling is the safe collection of a blood specimen from a vein, finger, or artery to run medical lab tests

Study summary

The biological samples and associated data will facilitate the successful implementation of the research collaboration between Bordeaux University Hospital and the University of Bordeaux on the pathophysiology of bronchopulmonary diseases. In the longer term, this research could lead to the discovery of new therapeutic targets for asthma, chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and acute respiratory distress syndrome.

Eligibility

Primary outcome measure(s)

• Describe tobacco consumption — At enrollment
  Number pack in years
• Describe tobacco statut — At enrollment
  Described as either non-smokers, former smokers or current smokers
• Description of demographic status — At enrollment
  Gender (male or female)
• Description of demographic status — At enrollment
  Age as years
• Description of demographic status — At enrollment
  Body Mass Index (BMI) (kg/m\^2)
• Mesure of lung function parameters — At enrollment
  FEV1: forced expiratory volume in 1 sec
• Mesure of lung function parameters — At enrollment
  FVC: forced vital capacity
• Mesure of lung function parameters — At enrollment
  FEF25-75: forced expiratory flow between 25 and 75% of the FVC
• Mesure of lung function parameters — At enrollment
  TLC: total lung capacity
• Mesure of lung function parameters — At enrollment
  RV: residual volume
• Describe of disease status — At enrollment
  Described as Healthy, COPD or Asthma
• Collection type — At enrollment
  Described as bronchial or lung specimens (frozen of embedded in paraffin), bronchial smooth muscle cells, bronchial epithelial cells, alveolar cells, arterial smooth muscle cells, arterial endothelial cells, fibrocytes, mesenchymal cells, lymphocytes, neutrophils, macrophages, organoïds.

Trial sites (1)

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