Correlation Between Capillary Refill Time and Perfusion Index in Critically Ill Patients

Condition(s) studied

Investigational drug(s) / intervention(s)

Microcirculation monitoring: Microcirculation monitoring by Capillary Refill Time (CRT) measurements

Microcirculation monitoring: Microcirculation monitoring by Perfusion Index (PI) measurements

Study summary

Assessment of capillary refill time (CRT) is a cornerstone of tissue perfusion monitoring in critically ill patients.

CRT measurement is performed by applying brief and gentle pressure (for a few seconds) to a small area of skin until blanching occurs. CRT is defined as the time, in seconds, required for the skin surface to return to its initial color after release of pressure.

Although CRT is a monitoring tool used on a daily basis in emergency departments and critical care units, its practical measurement modalities remain poorly standardized and time-consuming. Consequently, there is no consensus regarding the most reproducible bedside method for CRT assessment. Moreover, repeated CRT measurements during patient management are resource-intensive in terms of medical time and may raise issues related to healthcare staff availability.

The perfusion index (PI) is a marker of tissue perfusion derived from a pulse oximetry sensor. This monitoring device is routinely used in all critically ill patients. It is placed on the finger and worn continuously, including during patient transport.

Because PI measurement is automatic and continuous, establishing its correlation with CRT could allow for more precise tissue perfusion monitoring while reducing the time burden associated with bedside assessments in critically ill patients.

Eligibility

Primary outcome measure(s)

• Perfusion index (PI) threshold associated with abnormal capillary refill time (CRT) — At the inclusion
  The primary endpoint will be the PI threshold associated with abnormal CRT (\> 3 seconds). CRT is measured in seconds and PI in arbitrary units. These parameters will be measured simultaneously on each patient. Measurements will be performed at the inclusion of each patient.

Trial sites (2)

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