Women's Heart: Impact of Ultra-endurance and Hormonal Profile on Cardiac and Systemic Inflammatory Parameters in Female Runners

Condition(s) studied

Investigational drug(s) / intervention(s)

Echocardiography: 6 transthoracic echocardiography will be performed: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

Arterial ultrasound: 6 ultrasound of the carotid and femoral arteries will be performed: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

Blood sampling: 6 blood sampling (2 milliliters) will be performed: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

Scales and questionnaire: Before the race, during the race (refreshment station), and at the end of the race participant will be asked to complete the study questionnaire and scales. It is not possible to specify the intervention time, as this depends on the participants' running pace.

Vital signs: 6 measurements of blood pressure, heart rate, respiratory rate, pulse oxygen saturation, and muscle oxygen saturation will then be taken: 1 before the race, 3 during the race (refreshment station), 1 at the end of the race, 1 at the follow up visit 9 days after the race. It is not possible to specify the intervention time, as this depends on the participants' running pace.

Urinary test: Pregnancy test will be performed before the race.

Study summary

The goal of this clinical trial is to describe the cardiac and systemic inflammatory adaptations specific to women practicing ultra-endurance sports.

The objectives are to:

* Improve the understanding of cardiac and systemic inflammatory adaptations specific to women participating in ultra-endurance sports.
* Assess the relationship between observed cardiac and systemic inflammatory alterations and the relative levels of estrogen, testosterone, and progesterone.
* Describe the vascular adaptations specific to women participating in ultra-endurance sports.
* Examine the influence of defense mechanisms on the emotional dynamics observed during and after an ultra-endurance race.

Eligibility

Primary outcome measure(s)

• Cardiac function — Before the race, at the 3 refreshment stations, at the arrival of the race, 9 days after the race.
  Echocardiographic measurements of left ventricular ejection fraction as a percentage
• Systemic inflammatory parameters — Before the race, at the 3 refreshment stations, at the arrival of the race, 9 days after the race.
  Inflammatory profile adjusted for baseline

Trial sites (1)

More French Cardiology Society trials in France

Other trials for the same condition