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Clinical Trials in France / NCT07253363
Active, not recruiting Not applicable

Circulating Activin-A and FSTL3 in Precapillary Pulmonary Hypertension

NCT07253363 · tracked via the Priya Life Science France tracker
Sponsor
Assistance Publique - Hôpitaux de Paris
Phase
Not applicable
Started
2024-03-01
Last updated
2025-11-28

Condition(s) studied

Pulmonary Hypertension

Investigational drug(s) / intervention(s)

Biological collection

Biological collection: Serum, plasma, ADN

Study summary

The ACTIOBIO study aims to evaluate the prognostic value of Activin-A and FSTL3 in a large cohort of patients with precapillary pulmonary hypertension, including pulmonary arterial hypertension (Group 1), pulmonary hypertension associated with lung diseases (Group 3), and chronic thromboembolic pulmonary hypertension (Group 4).

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
1. Male or female ≥ 18 years of age 2. Precapillary PH documented by right heart catheterization: * mean pulmonary arterial pressure (mPAP) \> 20 mmHg, * pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg; * pulmonary vascular resistance (PVR) \> 2 WU 3. Pulmonary arterial hypertension (group 1) or PH associated with lung disease (group 3) or chronic thromboembolic PH (group 4) 4. Patient registered in the French PH registry 5. Patient capable of understanding the study procedures 6. Affiliation to a social security regime (or exemption)

Primary outcome measure(s)

Trial sites (1)

FacilityCityRegionStatus
Hôpital Bicêtre (AP-HP.Université Paris-Saclay), Service de Pneumologie et Soins Intensifs Le Kremlin-Bicêtre France

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07253363 on ClinicalTrials.gov ↗ ← All trials in France