The purpose of this study will be to study the association between the level of psychic symptomatic of anorexia nervosa (AN) (intensity of food restriction, symptoms of anxiety and depression) and alteration of host environment symbiosis and the mechanism (dysbiosis of intestinal microbiota, increase of intestinal permeability, immunity alteration and low-grade inflammation).
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria:
For patients:
* Patients aged ≥18 years;
* Anorexia according to DSM-5 and CIDI (Composite International Diagnostic Interview);
* Body mass index (BMI) (P/T2) \< 15;
* Hospitalization for nutrition rehabilitation;
* Covered by a health insurance;
* Informed consent form signed.
For Healthy Volunteers:
* Aged ≥18 years;
* 18.5 \< BMI (P/T2) \< 25;
* Covered by a health insurance;
* Informed consent form signed.
Exclusion Criteria:
For patients:
* Patients no-responding all criteria of DSM-5 or CIDI scores;
* Taken of antibiotic treatment 2 months / or laxativ 3 weeks before hospitalization;
* Somatic comorbidity should perturb intestinal microbiota (Crohn's disease, diabetes and all other chronic inflammatory diseases);
* Patients under guardianship;
* Patients covered by french AME scheme.
For Healthy Volunteers:
* Any disease should perturb intestinal microbiota;
* Recent ponderal variation;
* Taken of antibiotic treatment 2 months or laxativ 3 weeks before hospitalization;
* Under guardianship;
* Covered by french AME scheme.
Primary outcome measure(s)
Eating Disorder — at baseline By Eating Disorder Inventory (EDI-3)
Anxio-depressive symptomatologic assessements by HAD score — at baseline By HAD score
Anxio-depressive symptomatologic assessements by scale of Beck BDI 13 — at baseline By scale of Beck BDI 13
Anxio-depressive symptomatologic assessements by LSAS Lieboweitz social anxiety scale — at baseline By LSAS Lieboweitz social anxiety scale
Anxio-depressive symptomatologic assessements by MOCI — at baseline By Maudsley Obsessions and compulsions inventory (MOCI).
Anxio-depressive symptomatologic assessements — at baseline By HAD score, scale of Beck BDI 13, LSAS Lieboweitz social anxiety scale, Maudsley Obsessions and compulsions inventory (MOCI).
Physical exercise — at baseline By Global physical activity questionnaire (GPAQ)
Biological parameter — at baseline By serum serotonin level
Trial sites (1)
Facility
City
Region
Status
Service de Nutrition Clinique, Hôpital Paul Brousse (APHP)
Villejuif
France
Recruiting
More Assistance Publique - Hôpitaux de Paris trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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