Clinical Trials in France / NCT07191197
Recruiting
Not applicable
How do Patients With Amnesia Acquire New Knowledge?
NCT07191197 · tracked via the Priya Life Science France tracker
Condition(s) studied
AmnesiaMemory Disorder
Investigational drug(s) / intervention(s)
MRIPsychometric
MRI: structural and functional resting state MRI
Psychometric: 2 cognitive research tasks of semantic learning and neuropsychological assessment
Study summary
THE STUDY AIMS to constitute the largest group of patients with major memory impairment resulting from various etiology and specific lesions of the medial temporal lobe (MTL) and use a combined psychometric and neuroimaging approach to study the factors allowing these patients to successfully learn new semantic information.
Eligibility
Inclusion Criteria:
* Patients aged between 18 and 70 years
* Living in France since less than 20 years, being able to understand the French language, and have basic cultural knowledge as evaluated in classical clinical consultation
* Written agreement to participate in the study
* Intellectual capacities compatible with the cognitive tasks and signing of consent
* Affiliation to the French social security system
* For patients: bilateral brain lesion of the medial temporal lobe or the extended hippocampal system
Exclusion Criteria:
* Subjects under the age of 18 or over 70
* Contraindications for MRI (examples: wearers of a pacemaker or cardiac defibrillator, implanted equipment activated by an electrical, magnetic or mechanical system, wearers of haemostatic clips for intracerebral aneurysms or carotid arteries, wearers of orthopedic implants, claustrophobic)
* Refusal to be informed of an anomaly detected during the MRI
Primary outcome measure(s)
- Performance on Fast-Mapping semantic learning task — Baseline
* MRI measures: Anatomical MRI (T1-weighted) images will be analyzed using voxel-based lesion-symptom mapping (VLSM, MATLAB toolbox). Voxels will be classified as "lesioned" or "non-lesioned" in gray and white matter. * Behavioral measures: Performance on fast-mapping tasks (recognition scores). Those measurements will be aggregated : VLSM will be used to generate statistical maps of significant differences in fast-mapping recognition scores between lesioned vs. non-lesioned voxels across the T1 MRI. This method allows the evaluation of statistical relationships between specific brain lesions and behavioral deficits without requiring patient grouping by lesion site or behavioral threshold. VLSM integrates permutation testing for robust statistical inference and can analyze both discrete and graded lesions. As voxels may be located in either cortical or white matter regions, the approach enables the investigation of disconnection syndromes in addition to cortical syndromes.
Trial sites (2)
| Facility | City | Region | Status |
|---|---|---|---|
| University Hospital of Caen | Caen | France | Active Not Recruiting |
| University Hospital of Toulouse | Toulouse | France | Recruiting |
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Official registry record
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT07191197 on ClinicalTrials.gov ↗ ← All trials in France