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Clinical Trials in France / NCT07170865
Starting soon Observational

Dynamic Impact of NIV on Diaphragmatic Ultrasound in Patients With Amyotrophic Lateral Sclerosis

NCT07170865 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Grenoble
Phase
Observational
Started
2025-09-01
Last updated
2025-09-12

Condition(s) studied

Amyotrophic Lateral Sclerosis (ALS)Non Invasive Ventilation (NIV)

Study summary

The goal of this pilot observational study is to learn about the dynamic impact of the non invasive ventilation on the diaphragm in patient with amyotrophic lateral sclerosis. The main question it aims to answer : can diaphragmatic ultrasound detect differences in diaphragmatic motion (diaphragmactic excursion and diaphragmatic thickening between spontaneous breathing and non-invasive ventilation ?

Participants will receive diaphragmatic ultrasound assessments both under spontaneous breathing and during non-invasive ventilation on their day hospital evaluation for ventilatory support.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Adult patient (≥18 years old) * Diagnosis of bulbar or spinal amyotrophic lateral sclerosis (ALS) established by a neurologist * Indication for non-invasive ventilation (NIV) confirmed by the referring pulmonologist for daytime and/or nocturnal alveolar hypoventilation Exclusion Criteria: * Continuous (24-hour) non-invasive ventilation * Patient refusal to participate * Individual under legal guardianship or judicial protection

Primary outcome measure(s)

  • Composite : - Diaphragmatic excursion variation (DE) - Diaphragmatic thickening variation (DT) — Day 1
    Both DE and DT will be measured under spontaneous bretahing and under NIV. The outcomes will be compared, and the percentage variation between the two conditions will be recorded

Trial sites (1)

FacilityCityRegionStatus
CHU Grenoble-Alpes Grenoble Isère

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Other trials for the same condition

A Clinical Trial to Learn About the Effects of VHB937 in People With Amyotrophic Lateral Sclerosis (ALS) Active, not recruiting
Influence of Olfacto-gustatory Sensoriality on the Nutritional Status of Patients With Amyotrophic Lateral Sclerosis Recruiting
Music Therapy During NIV Implantation in Pediatric Intensive Care Units Recruiting
Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis Recruiting
Identification of Early Markers for ALS Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07170865 on ClinicalTrials.gov ↗ ← All trials in France