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Clinical Trials in France / NCT07170436
Starting soon Not applicable

Brain Areas of Cognitive Functions: a Study in Awake Surgery

NCT07170436 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Toulouse
Phase
Not applicable
Started
2025-11-01
Last updated
2025-09-12

Condition(s) studied

Cerebral Tumor

Investigational drug(s) / intervention(s)

Short version of cognitive testing during surgery

Short version of cognitive testing during surgery: Cognitive testing in 3 blocks of 3 minutes during awake surgery

Study summary

This research project focuses on low-level cognitive functions such as perception (auditory, visual, etc.) and high-level cognitive functions (memory, language, temporal estimation, etc.). It aims to better understand the brain bases of these functions as well as their overlap (i.e., brain bases considered to be involved in different functions).

To this end, various cognitive tasks will be performed before and during awake brain surgery, allowing us to determine the involvement of different areas in the task being performed. Comparing performance between the pre-test and the intraoperative test will help determine the potential involvement of the tested area.

Eligibility

Sex
ALL
Min age
18 Years
Max age
75 Years
Healthy volunteers
No
Inclusion Criteria: * Patients with a brain tumor * Aged 18 to 75 years * Signed informed consent * Vision that is corrected or adequate for the purposes of an experiment with visual stimuli * Hearing that is corrected or adequate for the purposes of an experiment with auditory stimuli * No known oculomotor disorder * Person affiliated with or benefiting from a social security scheme. * Free, informed, and written consent signed by the participant and the investigator (no later than the day of inclusion and before any examination required by the research) Exclusion Criteria: * Participants under protected status: guardianship, legal safeguard proceedings, or whose consent to participate in the experiment could be due to a severely altered psychological state, as determined by the medical team responsible for the surgery. * History of neurological disease affecting the central nervous system (Parkinson's, Alzheimer's, history of stroke or cerebral infarction) * Pregnant and/or breastfeeding women.

Primary outcome measure(s)

  • development of an atlas mapping the brain regions involved in each major cognitive function — One day after the inclusion
    Analysis of the percentage of "yes" responses during the intraoperative phase, taking into account the expected probability based on preoperative results. Preoperative performance data allows to determine an expected performance level during the intraoperative phase.

Trial sites (1)

FacilityCityRegionStatus
Service de Neurochirurgie, Hôpital Pierre Paul Riquet, Place du Docteur Baylac Toulouse Oui

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT07170436 on ClinicalTrials.gov ↗ ← All trials in France