Chrono-restricted Diet and Physical Activity as a New Preventive Strategy for Sarcopenia in Postmenopausal Women With Obesity and Type 2 Diabetes

Condition(s) studied

Investigational drug(s) / intervention(s)

Antidiabetic diet (control): Standard antidiabetic diet

eTRE diet: eTRE for a total duration of 12 weeks. During the eTRE, volunteers will have to eat and drink (meals + snacks, medication) exclusively during an 8-hour period which will extend between 6 a.m. (flexible: or 7 a.m. or 8 a.m.) in the morning and 2 p.m. (depending on the chosen start time: or 3 p.m. or 4 p.m.), which corresponds to a fasting period of 16 hours per day

Physical activity in the morning: Physical exercise will consist of 3 weekly morning sessions that will combine aerobic and resistance exercises

Physical activity in the afternoon: The physical exercise will consist of 3 weekly afternoon sessions that will combine aerobic and resistance exercises.

Study summary

The aim of TIMEDIAB is to demonstrate that early TRE (eTRE) combined to late (afternoon) exercise will outperform eTRE combined to morning exercise on muscle function as primary endpoint, and glucose homeostasis as secondary endpoint

Eligibility

Primary outcome measure(s)

• Change in skeletal muscle function — 4 years
  Change in skeletal muscle function, assessed by 30-CTS score at inclusion (baseline) and 12 weeks after diet/exercise program; This test is used to assess lower limb strength. The score corresponds to the total number of standing positions correctly performed within the allotted 30 seconds.

Trial sites (1)

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