olfactory stimulation: the patients have a sniff-test
functional MRI: patients have a an f MRI
Study summary
Studying the cerebral activity of children with Prader-Willi Syndrom (PWS) when the study propose to them nasal activations.
Eligibility
Sex
ALL
Min age
5 Years
Max age
7 Years
Healthy volunteers
No
Inclusion Criteria:
* child with a genetically confirmed diagnosis of PWS and for whom the genetic subtype (deletion or non deletion) has been identified
* Child aged between 5 and 7 years
* Child with a planned hospitalization at the Toulouse reference center for PWS
Exclusion Criteria:
* Presence of a contraindication to MRI
* Allergy to any of the fragrances used in the olfactory test
* Presence of an ENT infection such as rhinitis or sinusitis on the day of inclusion
* Reported anosmia
* Administrative problems.
Primary outcome measure(s)
hyperactivation of the right amygdala in young children with PWS not early OT-exposed and aged between 5 and 7 years in response to a sweet food odor compared to a neutral non-food odor. — day 1 intensity of right amygdala in fMRI
Trial sites (1)
Facility
City
Region
Status
University Hospital
Toulouse
France
More University Hospital, Toulouse trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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