The goal of this observational study is to compare the microbiological composition of the periodontal plaque of obese people undergoing bariatric surgery according to their Body Mass Index. The main question it aims to answer is:
Does obese patients have different microbiote according to their obesity?
Obesity being classified in two groups :
* group "obesity" for a BMI between 30 and 35
* versus "morbid obesity" group with a BMIabove 35.
Participants who are scheduled to undergo bariatric surgery as part of their regular medical care will answer questions about their quality of life, hygiene habits, and saliva and periodontal samples will be taken.
Eligibility
Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria:
* BMI greater than or equal to 30
* Be on the list of patients scheduled for bariatric surgery,
* Be able to receive information about the study and understand the information form in order to take part in the study. This implies mastering the French language,
Exclusion Criteria:
* Alcohol consumption \>30g/d (men) or 20g/d (women),
* Having taken antibiotics, prebiotics or probiotics in the month prior to inclusion (this has an influence on the composition of the patient's microbiota),
* During pregnancy or breastfeeding,
* For whom oral surgery is planned (surgery for benign or malignant tumours of the maxillary and mandibular bone bases), or with a history of oral surgery in the month prior to inclusion,
* At risk of infection (existence of one or more of the following known chronic infectious diseases: HIV, HBV, HCV and mononucleosis) and/or chronic renal insufficiency (creatinine clearance \< 60ml/min),
* Patients with a general pathology that contraindicates the performance of diagnostic procedures such as periodontal probing (patients at high risk of infective endocarditis according to the ANSM).
* Totally edentulous patients
Primary outcome measure(s)
Taxonomic analysis — before bariatric surgery Taxonomic analysis of the microbiological composition of the periodontal plaque between group 1 (obesity) and 2 (morbid obesity) : relative quantities of periodontal bacteria between group 1 (obesity) and 2 (morbid obesity)
Trial sites (1)
Facility
City
Region
Status
University Hospital of Toulouse
Toulouse
France
Recruiting
More University Hospital, Toulouse trials in France
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
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