Ireland
--:--IST
Recruiting Not applicable

Efficacy and Safety of Tran Cannula in Combined Pseudoexfoliative Glaucoma and Cataract Surgery Compared With Augmented Ocular Irrigation

NCT06979752 · tracked via the Priya Life Science France tracker
Phase
Not applicable
Started
2025-06-04
Last updated
2026-09-30

Condition(s) studied

Glaucoma, Open Angle, Pseudo-exfoliativeCataract

Investigational drug(s) / intervention(s)

Tran canulaaugmented irrigation

Tran canula: After phacoemulsification, implantation of the intraocular implant and aspiration of the viscoelastic, we connect the TranCanula® to the irrigation system. Then we treat the trabecular mesh.

augmented irrigation: After phacoemulsification, We use the classical aspiration cannula to irrigate the trabecular mesh.

Study summary

Pseudoexfoliative glaucoma is a glaucoma secondary to pseudoexfoliative syndrome; cataract surgery is often more difficult, with more complications. Tran's cannula is a single-use irrigation system designed for cleaning, with the pseudoexfoliative material remaining in the trabecular meshwork.

The main objective of this study is to evaluate the efficacy of the Tran cannula, in comparison with increased irrigation, in lowering intraocular pressure (IOP) in patients with pseudoexfoliative glaucoma and treated for glaucoma, and with an indication for isolated cataract surgery.

Eligibility

Sex
ALL
Min age
18 Years
Max age
—
Healthy volunteers
No
Inclusion Criteria: * Patients with cataract and early-to-moderate pseudoexfoliative glaucoma (GPX) scheduled for isolated cataract surgery. * Reliable visual field, Humphrey 24-2, Sita-Fast, with typical glaucoma alterations, and with mean deviation ≤-12 dB. * OCT with ganglion cell alterations and fibers typical of glaucoma. * Typical glaucomatous neuropathy * Slit-lamp signs of pseudoexfoliation. * Open angle (2 to 4, according to Shaffer classification) determined by gonioscopy. * Untreated eye pressure \>21 mmHg and \<33 mmHg Exclusion Criteria: * Presence of other ophthalmological pathologies (except cataract or mild dry eye) * History of intraocular surgery in the last 12 months, history of trauma * History of laser trabeculoplasty (TLA or SLT) in the previous 12 months * Visual acuity below "finger count * Myopia ≥ 6 dioptres, hyperopia ≥ 5 dioptres * Iridocorneal angle closure (and angle-closure glaucoma), any other type of non-pseudoexfoliative glaucoma, iris neovascularization * Pachymetry \< 490 μm or \> 620 μm; or corneal pathology or other condition that makes accurate IOP measurements with flattening tonometry, ultrasonic pachymetry or specular microscopy impossible. * Presence of severe systemic pathologies

Primary outcome measure(s)

  • Intraocular pressure measure — day 1, day 30, month 3, month 6 and month 12 after surgery

Trial sites (3)

FacilityCityRegionStatus
Hôpital Privé de la Baie Avranches France Recruiting
Fondation Rothschild Paris France Active Not Recruiting
Clinique de la Côte d'Emeraude St-Malo France Not Yet Recruiting
Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06979752 on ClinicalTrials.gov ↗ ← All trials in France