Timing of Anticoagulant Administration During Radial Access Percutaneous Coronary Intervention: the HERA-PCI Study (Heparin Early for Radial Access Percutaneous Coronary Intervention)

Condition(s) studied

Investigational drug(s) / intervention(s)

Administration of heparin after sheath insertion: Administration of heparin after sheath insertion

Administration of heparin prior to sheath insertion: Administration of heparin prior to sheath insertion

Study summary

While the reduced hemorrhagic risk of radial access for percutaneous coronary intervention compared to femoral access is well-established, its main complication remains radial artery occlusion, which can occur in up to 30% of patients. Anticoagulation is the primary preventive measure recommended in clinical practice to reduce the risk of this complication, typically involving heparin injection during the procedure in most centers. However, data on the effect of the timing of heparin injection are limited. The investigators hypothesize that injection of heparin before sheath insertion may reduce the rate of radial artery occlusion compared with injection after sheath insertion.

Eligibility

Primary outcome measure(s)

• Rate of radial artery occlusion — Day 1
  The primary endpoint is the rate of radial artery occlusion, as determined by Doppler ultrasound at day 1.

Trial sites (1)

More University Hospital, Strasbourg, France trials in France

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