Evaluation of Urinary Dysfunction in CANVAS Patients
Condition(s) studied
Investigational drug(s) / intervention(s)
Evaluation of urinary dysfunction in patients with CANVAS: Urinary dysfunction will be evaluated with neurologic exam, interrogation, urinary dairy report, self-questionnaires, biologic analysis, Sudoscan and urological exams
Study summary
The investigator wishes to evaluate the prevalence of urinary symptoms in patients diagnosed with Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome (CANVAS).
As much as one third of patients living with CANVAS experience symptoms of urinary system dysfunction. The primary objective of this study is to evaluate the incidence of urinary symptoms in these patients, as well as the potential complications that might occur at the level of the upper and lower urinary system. The investigator also wishes to analyse the connection between the severity of the neurological deficits, the presence of dysautonomia and the presence of urinary dysfunction. To that end, the data collected in the study will concern : a detailed neurological examination including SARA (Scale for the assessement and rating of ataxia) scale assessement, laboratory tests of the renal function, dysautonomia tests with Sudoscan and research of orthostatic hypotension, urinary function questionnaires, dysautonomia questionnaire, urodynamic tests and urinary system ultrasound.
Eligibility
Primary outcome measure(s)
- Evaluate the prevalence of urinary dysfunctions in patients with CANVAS genetically confirmed — at inclusion
The percentage of participants with urinary symptoms will be calculated by multiplying the number of participants with a USP (Urinary Symptom Profile) score greater than of equal to 1 by the total number of subjects included in the study, multiplied by 100. USP self-questionnaire was developped by the French Association of Urology. It aims to assess the symptoms of low urinary tract symptoms (LUTS) in men and women. It contains 13 items that assess stress urinary incontinence, bladder hyperreactivity and dysuria.
Trial sites (3)
| Facility | City | Region | Status |
|---|---|---|---|
| Nice University Hospital | Nice | Alpes Maritimes | Recruiting |
| Montpellier University hospital | Montpellier | Hérault | Not Yet Recruiting |
| Lille University Hospital | Lille | Nord | Not Yet Recruiting |
More Centre Hospitalier Universitaire de Nice trials in France
Other trials for the same condition
This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.
View NCT06817707 on ClinicalTrials.gov ↗ ← All trials in France