Pilot Study of PEnile TRAnsplantation - Vascularized Composite Allografts

Inclusion Criteria: * Patient ≥ 18 years and ≤ 60 years * Patient with traumatic penile severe defects (amputation), or congenital penile defects (micropenis) * ASA ≤ 2 * NYHA ≤ 1 * Creatinine clearance \> 60 mL/min (CKD-EPI) * Patients are willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up * Informed consent signed to participate to the study Exclusion Criteria: * Gender incongruence * Congenital penile defects resulting from exstrophy/epispadias * Penile malformation due to selh-half/self-amputation * Amputation for penile cancer * Other types of malignancy in remission for less than 5 years * Progressive malignant tumor * Presenting hepatitis B, hepatitis C, or HIV infection not controlled by appropriate anti-viral therapy * Uncontrolled arterial hypertension * Moderate renal failure : glomerular filtration rate of less than 60 mL/min per 1.73 m2 * EBV sero-negative recipient with EBV sero-positive graft, due to the risk of lymphoma * Non controlled chronic infection * Malignancy, Connective tissue disease * Amyloidosis * Unbalanced diabetes * Patient with a contraindication to performing an MRI examination * Contra-indication of Thymoglobuline: Hypersensitivity to rabbit proteins or to any of the excipients of Thymoglobuline, acute or chronic infections that contraindicate any additional immunosuppression, * Contra-inducation of tacrolimus: Hypersensitivity to tacrolimus or others macrolides, or any of the excipients of PROGRAF, * Contra-indication of Mycophenolate mofetil: in patients with hypersensitivity to mycophenolate mofetil, mycophenolic acid or any of the excipients, Hypersensitivity reactions to mycophenolate mofetil; * History of major psychiatric disorders \< 3 years (psychotic disorders, severe substance abuse, severe personality disorders) or persons under psychiatric care ; * Person deprived of their liberty by a judicial or administrative decision ; * Person admitted to a health or social institution for purposes other than research * Adult subjects to a legal protection measure (guardianship, curatorship) * Person not affiliated to a social security scheme of beneficiaries of a similar scheme