Effects of Non-invasive Ventilation Therapies on the Lung in Hypoxemic Chest Trauma Patients

NCT06735872 · tracked via the Priya Life Science France tracker

Sponsor

Hospices Civils de Lyon

Phase

Not applicable

Started

2025-04-22

Last updated

2025-06-24

Condition(s) studied

Lung TraumaLung Contusion

Investigational drug(s) / intervention(s)

Non invasive ventilation (NIV)High flow oxygen therapy (HFO)

Non invasive ventilation (NIV): This group will receive a unique 10-minute session of non invasive ventilation with standard parameters directly on the CT table. The treatment will be delivered via a naso-buccal mask. Prior to treatment, each participant will have a planned standard care chest CT. During the session, a senior intensivist watching for participant's comfort and safety.

High flow oxygen therapy (HFO): This group will receive a unique 10-minute session of high flow oxygen directly on the CT table. The treatment will be delivered via a nasal cannula. Prior to treatment, each participant will have a planned standard care chest CT. During the session, a senior intensivist watching for participant's comfort and safety.

Study summary

Chest trauma is common in traumatology. Its management is based on ventilatory therapies, among which non-invasive ventilation (NIV) is commonly used. Some studies have shown the benefit of this therapy in hypoxemic patients, avoiding intubation, reducing length of stay and healthcare costs, and even reducing mortality. However, these studies are old and underpowered. High flow oxygen therapy (HFO), which is frequently used in everyday practice, has only one study in chest trauma.

There is still a lack of data to really understand the effects of these techniques on the injured lung after trauma. Therefore, the investigators want to do a NIV or HFO session and directly assess the effects on participants' lungs by doing a CT at the end of the session.

This is a procedure carried out within five days of the initial trauma and consists of either a 10-minute session of non-invasive ventilation or a 10-minute session of high-flow oxygen therapy, depending on which arm the participant is allocated to.

Two chest CTs will be performed: the first as part of usual care before the non-invasive ventilation session or high flow oxygen therapy session, and the second immediately after the 10-minute session.

The investigator's objective is to demonstrate an improvement in lung recruitment with NIV or HFO using CT imaging.

Eligibility

Sex

ALL

Min age

18 Years

Max age

—

Healthy volunteers

Inclusion Criteria: * Age \> 18 years old * Chest trauma \< 5 days * At least 3 ribs fracture on initial CT-scan * Need of oxygen moderated to maintain monitoring oxygen saturation Sp02 \> 92% or partial pressure of arterial oxygen Pa02/ Fraction of inspired oxygen FiO2 \> 200 * Intensive Care Unit admission * Need a chest CT control during the five first days after the trauma Exclusion Criteria: * Patient intubated or with respiratory failure : measured or estimated Pa02/FiO2 \< 200 or indication for intubation (several with respiratory rate \> 35/min, abundant tracheal secretions, significant increase in work of accessory respiratory muscles on inspiration, signs of respiratory exhaustion on arterial blood gas with The potential of Hydrogen pH \< 7,3 or PaCO2 \> 50 mmHg, severe hypoxemia with PaO2/FiO2 ratio \< 100 or desaturation \< 88% for more than 5 minutes) * Inability to maintain 10 seconds of apnoea required for scan acquisition * Patient treated with ventilatory support by NIV or HFO in the 12 hours prior the investigation * Uncontrolled circulatory failure with need for introduction of Noradrenaline \> 0,15 ug/kg/min * Uncontrolled neurological failure with Glasgow Coma Scale (CGS \< 15 * Unstable facial trauma or with pneumocephalus or basilar skull trauma * Large, undrained pneumothorax with lateral separation at the level of the hilum \> 2 cm and extensive throughout the axillary line * Patients with identified cognitive impairment * Persons deprived of liberty, persons under protective measures * Persons not affiliated to a social security insurance * Current pregnancy or breastfeeding * Refusal to participate in the study

Primary outcome measure(s)

lung volume — At day 0
The primary outcome is evaluated by a quantitative method to compare lung volumes before and after ventilations sessions. The aim is to measure pulmonary recruitment which corresponds to the lung volume reaerated by ventilatory techniques (NIV and HFO), meaning the difference between the non-aerated lung volume between after and before the intervention. Thus, recruitment includes the partial or total re-aeration of lung areas initially not aerated before the intervention. The senior radiologist determine the non aerated volumes on mm3 thanks to a dedicated software. We will use a semi-automatic segmentation can be carried out quickly and reproducibly.

Trial sites (1)

Facility	City	Region	Status
Hopital Edouard Herriot	Lyon	Rhône	Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06735872 on ClinicalTrials.gov ↗ ← All trials in France