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Clinical Trials in France / NCT06688968
Recruiting Not applicable

Neuropsychological Profiles and Musical Engagement in Parkinson's and Alzheimer's Disease

NCT06688968 · tracked via the Priya Life Science France tracker
Sponsor
University Hospital, Montpellier
Phase
Not applicable
Started
2025-02-04
Last updated
2025-03-19

Condition(s) studied

Alzheimer Disease, Early OnsetParkinsons Disease with DementiaNon Pharmacological Intervention

Investigational drug(s) / intervention(s)

neuropsychologist interviewquestionnaire

neuropsychologist interview: It will take place either at the hospital or at the participant's home. This interview will consist of : * socio-demographic data collection * neuropsychological tests: * MMSE test (Mini Mental State Examination) cognitive function * RL-RI-16 test (16-item free recall/indexed recall test) * BECS test (Semantic knowledge assessment battery ) * WCST test (Wisconsin Card Sorting Test ) * Musical Cognition Test * Help from the participant's relative to answer certain questions, in particular the MuseEQ-24 questionnaire

questionnaire: The participant answers questionnaires: * Questionnaire MusEQ-24 self reported (Music Engagement Questionnaire) * Questionnaire BMRQ (Barcelona Reward Music Questionnaire) * Questionnaire SHAPS (Snaith-Hamilton Pleasure Scale) * Questionnaire LARS (Lille's Apathy Rating Scale) * Questionnaire PHQ-9 (Patient Health Questionnaire 9 items)

Study summary

The goal of this Multicenter observational pilot study is to Compare the specifics of musical engagement (behaviors related to music in everyday life) in subjects aged over 60 with Alzheimer s disease, Parkinson s disease and control subjects.

The main questions it aims to answer are:

1. The description of different profiles of musical engagement in early-stage AD, in PD and in healthy elderly subjects.
2. The extent of executive, mnestic and hedonic dysfunctions will impact differently on emotional engagement, autobiographical evocation and sensitivity to musical reward, and will therefore enable distinct profiles to be drawn up.

Participants will have an intervention consisting of an interview with a neuropsychologist lasting approximately 2 hours, including :

* A semi-structured interview to check the participants eligibility and gather demographic data.
* Neuropsychological tests and questionnaires will then be administered.
* A relative of the study participant will help complete questionnaires.

Eligibility

Sex
ALL
Min age
60 Years
Max age
—
Healthy volunteers
Accepted
Inclusion Criteria: General inclusion criteria: * 60 years and older * French-speaking and volunteering for the study * Living at home with a relative Alzheimer's disease inclusion criteria: * Biological diagnosis of probable Alzheimer's disease according to NINCDS-ADRDA criteria (McKhann et al., 1984) * MMSE greater than or equal to 20 Inclusion criteria Parkinson's disease : * Diagnosis of Idiopathic Parkinson's disease * MMSE greater than or equal to 20 Exclusion Criteria: * No known neurological pathologies (epilepsy and other non-degenerative CNS diseases) or psychiatric disorders (chronic psychosis and psychotic episodes) * Autistic disorders * History of stroke or head trauma * Unstable medical condition (cancer) * Subject unable to read and/or write * Hearing impairment without hearing aids * Refusal of consent after information * Persons unable to give consent, research carried out in emergency situations, etc.) * Non-affiliation with a social security scheme * Person deprived of liberty (by judicial or administrative decision, or forced hospitalization) * Person under legal protection (guardianship, curatorship, legal protection) * Person participating in another research project with an exclusion period still in progress

Primary outcome measure(s)

  • Comparison of the specificities of musical engagement (i.e., music-related behaviors in daily life) in Alzheimer's disease, Parkinson's disease, and among a population of healthy old adults. — Baseline
    Global score of informant version of the Music engagement Questionnaire (MusEQ-24) a 24 items questionnaire that delivers an overall score (ranging from 0 to 120) as well as a score for each of its 6 dimensions (ranging from 0 to 5) of musical engagement: Emotion, Daily life, Social, Response, Preferences and Identity. The higher the score, the greater the level of musical engagement.

Trial sites (3)

FacilityCityRegionStatus
Montpellier Seniors' Association Montpellier Hérault Not Yet Recruiting
CHU de Montpellier - CEPMo Montpellier Hérault Recruiting
CHU de Montpellier - CMRR Montpellier Hérault Not Yet Recruiting

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Official registry record

This page summarises publicly available registry data for informational purposes — not medical advice. Eligibility is determined by each study team; patients should discuss participation with their clinician.

View NCT06688968 on ClinicalTrials.gov ↗ ← All trials in France